Literature DB >> 23184776

Regulating specific growth factor signaling using immobilized branched ligands.

Michael W Toepke1, Nicholas A Impellitteri, Sheeny K Lan Levengood, Derek S Boeldt, Ian M Bird, William L Murphy.   

Abstract

VEGF-binding peptide ligands are incorporated into hydrogel microspheres and reduce the amount of growth factor in solution. VEGF binding affinity is enhanced by creating ligands with a dimer structure. The spheres are able to knock down VEGF-mediated HUVEC growth and reduce calcium signaling. The binding interaction is reversible, allowing the spheres to be used as a VEGF delivery vehicle.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 23184776      PMCID： PMC3925890          DOI： 10.1002/adhm.201200077

Source DB:  PubMed          Journal:  Adv Healthc Mater        ISSN： 2192-2640            Impact factor:   9.933


  12 in total

1.  Functional PEG-peptide hydrogels to modulate local inflammation induced by the pro-inflammatory cytokine TNFalpha.

Authors:  Chien-Chi Lin; Andrew T Metters; Kristi S Anseth
Journal:  Biomaterials       Date:  2009-06-27       Impact factor: 12.479

2.  Harnessing endogenous growth factor activity modulates stem cell behavior.

Authors:  Gregory A Hudalla; Nicholas A Kouris; Justin T Koepsel; Brenda M Ogle; William L Murphy
Journal:  Integr Biol (Camb)       Date:  2011-07-01       Impact factor: 2.192

3.  Heparin-regulated release of growth factors in vitro and angiogenic response in vivo to implanted hyaluronan hydrogels containing VEGF and bFGF.

Authors:  Daniel B Pike; Shenshen Cai; Kyle R Pomraning; Matthew A Firpo; Robert J Fisher; Xiao Zheng Shu; Glenn D Prestwich; Robert A Peattie
Journal:  Biomaterials       Date:  2006-06-30       Impact factor: 12.479

4.  [Ca2+]i signaling vs. eNOS expression as determinants of NO output in uterine artery endothelium: relative roles in pregnancy adaptation and reversal by VEGF165.

Authors:  Fu-Xian Yi; Derek S Boeldt; Ronald R Magness; Ian M Bird
Journal:  Am J Physiol Heart Circ Physiol       Date:  2011-01-14       Impact factor: 4.733

5.  Rationally designed peptides for controlled release of nerve growth factor from fibrin matrices.

Authors:  Stephanie M Willerth; Philip J Johnson; Dustin J Maxwell; Sarah R Parsons; Maria E Doukas; Shelly E Sakiyama-Elbert
Journal:  J Biomed Mater Res A       Date:  2007-01       Impact factor: 4.396

6.  Surfaces that sequester serum-borne heparin amplify growth factor activity.

Authors:  Gregory A Hudalla; Justin T Koepsel; William L Murphy
Journal:  Adv Mater       Date:  2011-10-26       Impact factor: 30.849

7.  Development of fibrin derivatives for controlled release of heparin-binding growth factors.

Authors:  S E Sakiyama-Elbert; J A Hubbell
Journal:  J Control Release       Date:  2000-04-03       Impact factor: 9.776

8.  VEGF-Trap: a VEGF blocker with potent antitumor effects.

Authors:  Jocelyn Holash; Sam Davis; Nick Papadopoulos; Susan D Croll; Lillian Ho; Michelle Russell; Patricia Boland; Ray Leidich; Donna Hylton; Elena Burova; Ella Ioffe; Tammy Huang; Czeslaw Radziejewski; Kevin Bailey; James P Fandl; Tom Daly; Stanley J Wiegand; George D Yancopoulos; John S Rudge
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-12       Impact factor: 11.205

Review 9.  The biology of VEGF and its receptors.

Authors:  Napoleone Ferrara; Hans-Peter Gerber; Jennifer LeCouter
Journal:  Nat Med       Date:  2003-06       Impact factor: 53.440

10.  Potent inhibition of angiogenesis by D,L-peptides derived from vascular endothelial growth factor receptor 2.

Authors:  Christine Piossek; Karl-Heinz Thierauch; Jens Schneider-Mergener; Rudolf Volkmer-Engert; Martin F Bachmann; Thomas Korff; Hellmut G Augustin; Lothar Germeroth
Journal:  Thromb Haemost       Date:  2003-09       Impact factor: 5.249
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  10 in total

1.  Linkage Groups within Thiol-Ene Photoclickable PEG Hydrogels Control In Vivo Stability.

Authors:  Michael D Hunckler; Juan D Medina; Maria M Coronel; Jessica D Weaver; Cherie L Stabler; Andrés J García
Journal:  Adv Healthc Mater       Date:  2019-05-21       Impact factor: 9.933

Review 2.  Design of growth factor sequestering biomaterials.

Authors:  David G Belair; Ngoc Nhi Le; William L Murphy
Journal:  Chem Commun (Camb)       Date:  2014-09-03       Impact factor: 6.222

3.  Regulating VEGF signaling in platelet concentrates via specific VEGF sequestering.

Authors:  David G Belair; Ngoc Nhi Le; William L Murphy
Journal:  Biomater Sci       Date:  2016-03-24       Impact factor: 6.843

4.  Adaptable poly(ethylene glycol) microspheres capable of mixed-mode degradation.

Authors:  M Parlato; A Johnson; G A Hudalla; W L Murphy
Journal:  Acta Biomater       Date:  2013-08-17       Impact factor: 8.947

5.  Thiol-norbornene photo-click hydrogels for tissue engineering applications.

Authors:  Chien-Chi Lin; Chang Seok Ki; Han Shih
Journal:  J Appl Polym Sci       Date:  2015-02-20       Impact factor: 3.125

Review 6.  Context clues: the importance of stem cell-material interactions.

Authors:  Andrew S Khalil; Angela W Xie; William L Murphy
Journal:  ACS Chem Biol       Date:  2014-01-03       Impact factor: 5.100

7.  Differential regulation of angiogenesis using degradable VEGF-binding microspheres.

Authors:  David G Belair; Michael J Miller; Shoujian Wang; Soesiawati R Darjatmoko; Bernard Y K Binder; Nader Sheibani; William L Murphy
Journal:  Biomaterials       Date:  2016-03-16       Impact factor: 12.479

8.  Specific VEGF sequestering to biomaterials: influence of serum stability.

Authors:  David G Belair; William L Murphy
Journal:  Acta Biomater       Date:  2013-06-29       Impact factor: 8.947

9.  Serum-dependence of affinity-mediated VEGF release from biomimetic microspheres.

Authors:  David G Belair; Andrew S Khalil; Michael J Miller; William L Murphy
Journal:  Biomacromolecules       Date:  2014-05-12       Impact factor: 6.988

10.  Determination of The Properties of Rat Brain Thermostable Protein Complex which Inhibit Cell Proliferation.

Authors:  Diana Dzidziguri; Irina Modebadze; Ekaterine Bakuradze; Giorgi Mosidze; Manana Berulava
Journal:  Cell J       Date:  2017-11-04       Impact factor: 2.479
  10 in total

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