BACKGROUND: A few studies have reported that the quantity of selected cytokines/chemokines in breast milk might be associated with atopic dermatitis (AD). Using the multiplex cytokine assay system, we examined cytokines/chemokines in human milk in order to identify new biomarkers related to AD. METHODS: We recruited 49 infants with or without AD who participated in a birth cohort and measured the concentrations of cytokines/chemokines in the colostrum (collected within 4-5 days after birth) and mature milk (collected at 1 month postpartum) received by the infants. RESULTS: There were significant differences in the concentrations of interleukin (IL)-1β and IL-12p40 in the colostrum, and in those of IL-4, eotaxin, granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage colony-stimulating factor (GM-CSF), interferon (IFN)-α2 and MIP-1α in the mature milk between the milk received by infants who developed AD at the age of 6 months and that received by the control infants. There was weak to moderate correlation between those 6 cytokines/chemokines in mature milk. Atopic history and IgE levels of mothers were not related to cytokine/chemokine concentrations in breast milk. Logistic regression analyses showed that high levels of eotaxin in the mature milk were a risk for the development of AD at 6 months of age. CONCLUSION: These results suggest that several cytokines/chemokines, especially eotaxin, are potential biomarkers for development of AD in early infancy.
BACKGROUND: A few studies have reported that the quantity of selected cytokines/chemokines in breast milk might be associated with atopic dermatitis (AD). Using the multiplex cytokine assay system, we examined cytokines/chemokines in human milk in order to identify new biomarkers related to AD. METHODS: We recruited 49 infants with or without AD who participated in a birth cohort and measured the concentrations of cytokines/chemokines in the colostrum (collected within 4-5 days after birth) and mature milk (collected at 1 month postpartum) received by the infants. RESULTS: There were significant differences in the concentrations of interleukin (IL)-1β and IL-12p40 in the colostrum, and in those of IL-4, eotaxin, granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage colony-stimulating factor (GM-CSF), interferon (IFN)-α2 and MIP-1α in the mature milk between the milk received by infants who developed AD at the age of 6 months and that received by the control infants. There was weak to moderate correlation between those 6 cytokines/chemokines in mature milk. Atopic history and IgE levels of mothers were not related to cytokine/chemokine concentrations in breast milk. Logistic regression analyses showed that high levels of eotaxin in the mature milk were a risk for the development of AD at 6 months of age. CONCLUSION: These results suggest that several cytokines/chemokines, especially eotaxin, are potential biomarkers for development of AD in early infancy.
Authors: Kelley L Baumgartel; Maureen W Groer; Susan M Cohen; Dianxu Ren; Diane L Spatz; Yvette P Conley Journal: J Hum Lact Date: 2016-06-01 Impact factor: 2.219
Authors: Oleg Blyuss; Ka Yan Cheung; Jessica Chen; Callum Parr; Loukia Petrou; Alina Komarova; Maria Kokina; Polina Luzan; Egor Pasko; Alina Eremeeva; Dmitrii Peshko; Vladimir I Eliseev; Sindre Andre Pedersen; Meghan B Azad; Kirsi M Jarvinen; Diego G Peroni; Valerie Verhasselt; Robert J Boyle; John O Warner; Melanie R Simpson; Daniel Munblit Journal: Nutrients Date: 2019-10-10 Impact factor: 5.717