Jin-Ho Choi1, Han-Wook Yoo. 1. Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
Abstract
PURPOSE OF REVIEW: The aim of this review is to summarize recent advances regarding the genetic components of the complex and coordinated process of puberty, an update of the genes implicated in disorders of puberty, the endocrinologic changes of puberty, and influences of environment in the light of our current understanding of the mechanism of the onset of puberty. RECENT FINDINGS: The timing of puberty varies greatly in the general population among ethnic groups throughout the world, suggesting the genetic control of puberty. Several studies on the pathological conditions of pubertal onset provide unique information about the interactions of either the genetic susceptibility of or environmental influences on hypothalamic control of pubertal onset. However, these findings suggested that no isolated pathway or external factor is solely responsible for the neuroendocrine control of puberty. SUMMARY: Puberty is initiated by gonadotropin-releasing hormone from the hypothalamus followed by a complex sequence of endocrine changes and is regulated by both genetic and environmental factors. New attempts to use genetics and genomics might enhance our understanding of the spectrum of pubertal development.
PURPOSE OF REVIEW: The aim of this review is to summarize recent advances regarding the genetic components of the complex and coordinated process of puberty, an update of the genes implicated in disorders of puberty, the endocrinologic changes of puberty, and influences of environment in the light of our current understanding of the mechanism of the onset of puberty. RECENT FINDINGS: The timing of puberty varies greatly in the general population among ethnic groups throughout the world, suggesting the genetic control of puberty. Several studies on the pathological conditions of pubertal onset provide unique information about the interactions of either the genetic susceptibility of or environmental influences on hypothalamic control of pubertal onset. However, these findings suggested that no isolated pathway or external factor is solely responsible for the neuroendocrine control of puberty. SUMMARY: Puberty is initiated by gonadotropin-releasing hormone from the hypothalamus followed by a complex sequence of endocrine changes and is regulated by both genetic and environmental factors. New attempts to use genetics and genomics might enhance our understanding of the spectrum of pubertal development.
Authors: Ashley M Cattran; Heidi J Kalkwarf; Susan M Pinney; Bin Huang; Frank M Biro Journal: J Pediatr Adolesc Gynecol Date: 2014-07-19 Impact factor: 1.814
Authors: Dan J Nonneman; James F Schneider; Clay A Lents; Ralph T Wiedmann; Jeffrey L Vallet; Gary A Rohrer Journal: BMC Genet Date: 2016-02-29 Impact factor: 2.797
Authors: Hui Juan Zhu; Su Juan Li; Hui Pan; Naishi Li; Dian Xi Zhang; Lin Jie Wang; Hong Bo Yang; Qinyong Wu; Feng Ying Gong Journal: Int J Endocrinol Date: 2016-11-20 Impact factor: 3.257
Authors: Ming Hao; Jiang-Feng Mao; Qing-Bo Guan; Long Tian; Hu Han; Hong-En Lei; Dong-Mei Zheng; Zhen-Hua Tian; Min Nie; Xi Wang; Bing-Qing Yu; Yin-Jie Gao; Xue-Yan Wu Journal: Ann Transl Med Date: 2021-06