| Literature DB >> 2318312 |
A Brossi1, O Boyé, A Muzaffar, H J Yeh, V Toome, B Wegrzynski, C George.
Abstract
The aS,7S-absolute configuration of (-)-colchicine (1) and (-)-N-acetylcolchinol methyl ether (3, NCME) suggested on the basis of 1H NMR data and negative Cotton effects at about 260 nm (EtOH) is firmly established by an X-ray analysis of urea 5, a compound derived from 3. Binding of these compounds to tubulin requires an aS-configuration of the biaryl system.Entities:
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Year: 1990 PMID： 2318312 DOI： 10.1016/0014-5793(90)80139-a
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124