Literature DB >> 23183093

Toll-like receptor 9 processing: the key event in Toll-like receptor 9 activation?

Stefan Bauer1.   

Abstract

Toll-like receptor 9 (TLR9) mediated recognition of viral and bacterial DNA activates the innate immune system. Recently proteolytic cleavage of TLR9 in the endosomal/lysosomal compartment by proteases such as cathepsins and asparagine endopeptidase (AEP) has been identified as a key step for TLR9 activation by CpG-DNA. However, mutants of TLR9 that do not affect proteolytic cleavage lost their functionality suggesting a more complex scenario of TLR9 activation.
Copyright © 2012 Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 23183093     DOI： 10.1016/j.imlet.2012.11.003

Source DB:  PubMed          Journal:  Immunol Lett        ISSN： 0165-2478            Impact factor:   3.685


  14 in total

1.  Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.

Authors:  Lixia Zhao; Tian Hua; Christopher Crowley; Heng Ru; Xiangmin Ni; Neil Shaw; Lianying Jiao; Wei Ding; Lu Qu; Li-Wei Hung; Wei Huang; Lei Liu; Keqiang Ye; Songying Ouyang; Genhong Cheng; Zhi-Jie Liu
Journal:  Cell Res       Date:  2014-01-10       Impact factor: 25.617

2.  An Overdose of the Arabidopsis Coreceptor BRASSINOSTEROID INSENSITIVE1-ASSOCIATED RECEPTOR KINASE1 or Its Ectodomain Causes Autoimmunity in a SUPPRESSOR OF BIR1-1-Dependent Manner.

Authors:  Ana Domínguez-Ferreras; Marta Kiss-Papp; Anna Kristina Jehle; Georg Felix; Delphine Chinchilla
Journal:  Plant Physiol       Date:  2015-05-05       Impact factor: 8.340

3.  Regulation of sterile α- and armadillo motif (SARM) containing protein expression in Pam2CSK4- and Pam3CSK4-activated mouse macrophage cell line (RAW264.7) requires TLR9.

Authors:  Matsayapan Pudla; Panthong Kulsantiwong; Chanya Srisaowakarn; Pongsak Utaisincharoen
Journal:  Inflamm Res       Date:  2017-09-09       Impact factor: 4.575

4.  Crystal structure of the C-terminal domain of mouse TLR9.

Authors:  Bernard Collins; Ian A Wilson
Journal:  Proteins       Date:  2014-06-16

5.  The exosomal integrin α5β1/AEP complex derived from epithelial ovarian cancer cells promotes peritoneal metastasis through regulating mesothelial cell proliferation and migration.

Authors:  Xiaoduan Li; Meiling Tang; Qinyi Zhu; Xinjing Wang; Yingying Lin; Xipeng Wang
Journal:  Cell Oncol (Dordr)       Date:  2020-02-21       Impact factor: 6.730

6.  Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFα release via RAGE- and TLR9-responsive plasmacytoid dendritic cells.

Authors:  Mark W Julian; Guohong Shao; Zachary C Vangundy; Tracey L Papenfuss; Elliott D Crouser
Journal:  PLoS One       Date:  2013-08-12       Impact factor: 3.240

7.  Piperidylmethyloxychalcone improves immune-mediated acute liver failure via inhibiting TAK1 activity.

Authors:  Sun Hong Park; Jeong-Ah Kwak; Sang-Hun Jung; Byeongwoo Ahn; Won-Jea Cho; Cheong-Yong Yun; Chang Seon Na; Bang Yeon Hwang; Jin Tae Hong; Sang-Bae Han; Youngsoo Kim
Journal:  Exp Mol Med       Date:  2017-11-17       Impact factor: 8.718

8.  Inactivated ORF virus shows antifibrotic activity and inhibits human hepatitis B virus (HBV) and hepatitis C virus (HCV) replication in preclinical models.

Authors:  Daniela Paulsen; Andreas Urban; Andreas Knorr; Claudia Hirth-Dietrich; Angela Siegling; Hans-Dieter Volk; Andrew A Mercer; Andreas Limmer; Beatrix Schumak; Percy Knolle; Helga Ruebsamen-Schaeff; Olaf Weber
Journal:  PLoS One       Date:  2013-09-16       Impact factor: 3.240

Review 9.  Toll-like receptor 9 in breast cancer.

Authors:  Jouko Sandholm; Katri S Selander
Journal:  Front Immunol       Date:  2014-07-22       Impact factor: 7.561

10.  Changes of KEAP1/NRF2 and IKB/NF-κB Expression Levels Induced by Cell-Free DNA in Different Cell Types.

Authors:  Svetlana V Kostyuk; Lev N Porokhovnik; Elizaveta S Ershova; Elena M Malinovskaya; Marina S Konkova; Larisa V Kameneva; Olga A Dolgikh; Vladimir P Veiko; Vladimir M Pisarev; Andrew V Martynov; Vasilina A Sergeeva; Andrew A Kaliyanov; Anton D Filev; Julia M Chudakova; Margarita S Abramova; Serguey I Kutsev; Vera L Izhevskaya; Nataliya N Veiko
Journal:  Oxid Med Cell Longev       Date:  2018-03-20       Impact factor: 6.543
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