Literature DB >> 23182398

Epithelial to mesenchymal transition in head and neck squamous cell carcinoma.

Ashley Smith1, Theodoros N Teknos, Quintin Pan.   

Abstract

Epithelial to mesenchymal transition (EMT) is a dynamic cellular process that is essential for the development of metastatic disease. During EMT, a tumor cell with epithelial characteristics transitions to a tumor cell with mesenchymal characteristics through modulation of cell polarity and adhesion. Two hallmark EMT proteins, E-Cadherin and Vimentin, are tightly controlled during EMT through multiple signal transduction pathways. Epidermal growth factor (EGF) and transforming growth factorβ (TGFβ) promote EMT by regulating a distinct set of transcription factors, including Snail and Twist. Snail, Twist, and Slug are integral to the induction of EMT through direct regulation of genes involved in cellular adhesion, migration, and invasion. This review highlights the current literature on EMT in HNSCC. Understanding the role of EMT will provide insight to the pathogenesis of disease progression and may lead to the development of novel anti-cancer therapeutics for metastatic HNSCC.
Copyright © 2012 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 23182398      PMCID： PMC3586749          DOI： 10.1016/j.oraloncology.2012.10.009

Source DB:  PubMed          Journal:  Oral Oncol        ISSN： 1368-8375            Impact factor:   5.337


  73 in total

Review 1.  Biomarkers for epithelial-mesenchymal transitions.

Authors:  Michael Zeisberg; Eric G Neilson
Journal:  J Clin Invest       Date:  2009-06-01       Impact factor: 14.808

Review 2.  Stat3 orchestrates tumor development and progression: the Achilles' heel of head and neck cancers?

Authors:  Muneyuk Masuda; T Wakasaki; Masumi Suzui; Satoshi Toh; Andrew K Joe; I B Weinstein
Journal:  Curr Cancer Drug Targets       Date:  2010-02       Impact factor: 3.428

3.  Transcription factors Snail, Slug, Twist, and SIP1 in spindle cell carcinoma of the head and neck.

Authors:  Nika Kojc; Nina Zidar; Nina Gale; Mario Poljak; Kristina Fujs Komlos; Antonio Cardesa; Heinz Höfler; Karl-Friedrich Becker
Journal:  Virchows Arch       Date:  2009-04-21       Impact factor: 4.064

4.  Epithelial-mesenchymal transition downregulates laminin alpha5 chain and upregulates laminin alpha4 chain in oral squamous carcinoma cells.

Authors:  Minna Takkunen; Mari Ainola; Noora Vainionpää; Reidar Grenman; Manuel Patarroyo; Antonio García de Herreros; Yrjö T Konttinen; Ismo Virtanen
Journal:  Histochem Cell Biol       Date:  2008-05-22       Impact factor: 4.304

Review 5.  The basics of epithelial-mesenchymal transition.

Authors:  Raghu Kalluri; Robert A Weinberg
Journal:  J Clin Invest       Date:  2009-06       Impact factor: 14.808

6.  Truncated P-cadherin is produced in oral squamous cell carcinoma.

Authors:  Richard Bauer; Albert Dowejko; Oliver Driemel; A-K Bosserhoff; T E Reichert
Journal:  FEBS J       Date:  2008-07-11       Impact factor: 5.542

7.  Cadherin-catenin complex and transcription factor Snail-1 in spindle cell carcinoma of the head and neck.

Authors:  Nina Zidar; Nina Gale; Nika Kojc; Metka Volavsek; Antonio Cardesa; Llucia Alos; Heinz Höfler; Kareen Blechschmidt; Karl-Friedrich Becker
Journal:  Virchows Arch       Date:  2008-08-19       Impact factor: 4.064

Review 8.  Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers.

Authors:  Michèle Sabbah; Shahin Emami; Gérard Redeuilh; Sylvia Julien; Grégoire Prévost; Amazia Zimber; Radia Ouelaa; Marc Bracke; Olivier De Wever; Christian Gespach
Journal:  Drug Resist Updat       Date:  2008-08-20       Impact factor: 18.500

9.  Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells.

Authors:  Kyoung-Ok Hong; Ji-Hong Kim; Ji-Soo Hong; Hye-Jung Yoon; Jae-Il Lee; Sam-Pyo Hong; Seong-Doo Hong
Journal:  J Exp Clin Cancer Res       Date:  2009-02-26

10.  Inhibition of Aurora-A suppresses epithelial-mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells.

Authors:  Xiang-Bo Wan; Zi-Jie Long; Min Yan; Jie Xu; Liang-Ping Xia; Li Liu; Yan Zhao; Xue-Fei Huang; Xian-Ren Wang; Xiao-Feng Zhu; Ming-Huang Hong; Quentin Liu
Journal:  Carcinogenesis       Date:  2008-07-30       Impact factor: 4.944
View more
  94 in total

Review 1.  Expression and Significance of Cadherins and Its Subtypes in Development and Progression of Oral Cancers: A Review.

Authors:  Yogesh Chand Rajwar; Nitul Jain; Gouri Bhatia; Neha Sikka; Balram Garg; Esha Walia
Journal:  J Clin Diagn Res       Date:  2015-05-01

2.  Histologic pattern of invasion and epithelial-mesenchymal phenotype predict prognosis in squamous carcinoma of the head and neck.

Authors:  Gregory T Wolf; William Winter; Emily Bellile; Ariane Nguyen; C R Donnelly; Jonathan B McHugh; Dafydd Thomas; Lahin Amlani; Laura Rozek; Yu L Lei
Journal:  Oral Oncol       Date:  2018-10-22       Impact factor: 5.337

3.  Overexpression of N-cadherin and β-catenin correlates with poor prognosis in patients with nasopharyngeal carcinoma.

Authors:  Hong Sun; Mingyu Liu; Xuewen Wu; Chunguang Yang; Yanni Zhang; Zhenhang Xu; Kelei Gao; Fengjun Wang
Journal:  Oncol Lett       Date:  2017-01-25       Impact factor: 2.967

4.  The NOTCH4-HEY1 Pathway Induces Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.

Authors:  Takahito Fukusumi; Theresa W Guo; Akihiro Sakai; Mizuo Ando; Shuling Ren; Sunny Haft; Chao Liu; Panomwat Amornphimoltham; J Silvio Gutkind; Joseph A Califano
Journal:  Clin Cancer Res       Date:  2017-11-16       Impact factor: 12.531

5.  Suppression of migration, invasion, and metastasis of cisplatin-resistant head and neck squamous cell carcinoma through IKKβ inhibition.

Authors:  Jipei Liao; Zejia Yang; Brandon Carter-Cooper; Elizabeth T Chang; Eun Yong Choi; Bhaskar Kallakury; Xuefeng Liu; Rena G Lapidus; Kevin J Cullen; Hancai Dan
Journal:  Clin Exp Metastasis       Date:  2020-02-04       Impact factor: 5.150

6.  Targeted silencing of CXCR4 inhibits epithelial-mesenchymal transition in oral squamous cell carcinoma.

Authors:  Yuansheng Duan; Shu Zhang; Longlong Wang; Xuan Zhou; Qinghua He; Su Liu; Kai Yue; Xudong Wang
Journal:  Oncol Lett       Date:  2016-07-11       Impact factor: 2.967

7.  Interactions of human MSC with head and neck squamous cell carcinoma cell line PCI-13 reduce markers of epithelia-mesenchymal transition.

Authors:  F Böhrnsen; M Fricke; C Sander; A Leha; H Schliephake; F J Kramer
Journal:  Clin Oral Investig       Date:  2014-10-28       Impact factor: 3.573

8.  CD271 Confers an Invasive and Metastatic Phenotype of Head and Neck Squamous Cell Carcinoma through the Upregulation of Slug.

Authors:  Man Ki Chung; Young Ho Jung; Joon Kyoo Lee; Soo Youn Cho; Oihana Murillo-Sauca; Ravindra Uppaluri; June Ho Shin; John B Sunwoo
Journal:  Clin Cancer Res       Date:  2017-12-05       Impact factor: 12.531

9.  The role of epithelial-mesenchymal transition in squamous cell carcinoma of the oral cavity.

Authors:  Nina Zidar; Emanuela Boštjančič; Marija Malgaj; Nina Gale; Tadej Dovšak; Vojko Didanovič
Journal:  Virchows Arch       Date:  2017-07-12       Impact factor: 4.064

10.  ZEB1 promotes the progression and metastasis of cervical squamous cell carcinoma via the promotion of epithelial-mesenchymal transition.

Authors:  Yihui Ma; Xiangyu Zheng; Jun Zhou; Ying Zhang; Kuisheng Chen
Journal:  Int J Clin Exp Pathol       Date:  2015-09-01
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.