| Literature DB >> 23182091 |
Ahmed Kamal1, Jaki R Tamboli, M V P S Vishnuvardhan, S F Adil, V Lakshma Nayak, S Ramakrishna.
Abstract
A series of different heteroaromatic linked 4β-amidopodophyllotoxin conjugates (16a-i, 17a-i and 18a-d) were synthesized and evaluated for anticancer activity against five human cancer cell lines. Among the series, one of the compound 17g showed significant antiproliferative activity in A549 (lung cancer) cell line. Flow cytometric analysis showed that 17g arrested the cell cycle in the G2/M phase leading to caspase-3 dependent apoptotic cell death. Further, Hoechst 33258 staining and DNA fragmentation assay also suggests that 17g induces cell death by apoptosis.Entities:
Mesh：
Substances：
Year: 2012 PMID： 23182091 DOI： 10.1016/j.bmcl.2012.10.099
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823