| Literature DB >> 23182087 |
Shunmugam Nagarajan1, Syamantak Majumder, Upendra Sharma, Saranya Rajendran, Neeraj Kumar, Suvro Chatterjee, Bikram Singh.
Abstract
Benzothiazole and benzimidazole containing phthalimide derivatives (NK037, NK041, NK042, NK0139A and NK0148) have been synthesized and their anti-angiogenic activity was evaluated using ex vivo egg yolk angiogenesis model. A comparative study with pure thalidomide (NKTA) has also been performed to describe the efficacy of these derivatives in blocking angiogenesis. NK037, NK041 and NK042 were equally potent in blocking egg yolk angiogenesis and the anti-angiogenesis effect was higher than NKTA suggesting the efficacy of these three derivatives in blocking angiogenesis when compare to control. Other two derivatives NK0139A and NK0148 showed effect less than NKTA and stronger than control in ex vivo angiogenesis.Entities:
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Year: 2012 PMID： 23182087 DOI： 10.1016/j.bmcl.2012.10.106
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823