OBJECTIVE: To determine seroprevalence of hepatitis C virus (HCV), human immunodeficiency virus (HIV), and hepatitis B virus (HBV) and associated factors among transfused children. METHODS: A multicenter cross-sectional study of transfused children aged between 18 mo and 13 y old was conducted in 4 hospitals in Kinshasa. Blood samples were collected for the detection of Hepatitis B surface antigen (HBsAg) and antibodies to HCV, HIV 1 and 2. RESULTS: A total of 177 (47.7 %) boys and 194 (52.3 %) girls participated in the study. The median age was 59.5 mo (Interquartile range IQR = 60.6). The prevalence rates of HCV, HBV, and HIV infection were 13.5 %, 1.6 %, and 1.3 %, respectively. Frequency of transfusion events were significantly associated with HCV (p < 0.001) and HIV (p < 0.05) infections. CONCLUSIONS: HCV infection was by far more frequently identified than HBV and HIV infections among Congolese transfused children. Frequency of transfusion events was the only significant risk factor associated with HCV and HIV infections but not for HBV.
OBJECTIVE: To determine seroprevalence of hepatitis C virus (HCV), human immunodeficiency virus (HIV), and hepatitis B virus (HBV) and associated factors among transfused children. METHODS: A multicenter cross-sectional study of transfused children aged between 18 mo and 13 y old was conducted in 4 hospitals in Kinshasa. Blood samples were collected for the detection of Hepatitis B surface antigen (HBsAg) and antibodies to HCV, HIV 1 and 2. RESULTS: A total of 177 (47.7 %) boys and 194 (52.3 %) girls participated in the study. The median age was 59.5 mo (Interquartile range IQR = 60.6). The prevalence rates of HCV, HBV, and HIV infection were 13.5 %, 1.6 %, and 1.3 %, respectively. Frequency of transfusion events were significantly associated with HCV (p < 0.001) and HIV (p < 0.05) infections. CONCLUSIONS:HCV infection was by far more frequently identified than HBV and HIV infections among Congolese transfused children. Frequency of transfusion events was the only significant risk factor associated with HCV and HIV infections but not for HBV.
Authors: A Moore; G Herrera; J Nyamongo; E Lackritz; T Granade; B Nahlen; A Oloo; G Opondo; R Muga; R Janssen Journal: Lancet Date: 2001-08-25 Impact factor: 79.321
Authors: Lina Cunha; Chloé Plouzeau; Pierre Ingrand; Joël Paulo Samo Gudo; Isabelle Ingrand; José Mondlane; Michel Beauchant; Gérard Agius Journal: J Med Virol Date: 2007-12 Impact factor: 2.327
Authors: Rosauro Varo; W Chris Buck; Peter N Kazembe; Sam Phiri; Diavolana Andrianarimanana; Ralf Weigel Journal: J Trop Pediatr Date: 2016-02-15 Impact factor: 1.165