Literature DB >> 23180244

Rv3080c regulates the rate of inhibition of mycobacteria by isoniazid through FabD.

Ruma Kumari1, Richa Saxena, Sameer Tiwari, Dinesh K Tripathi, Kishore K Srivastava.   

Abstract

The mycobacterial FASII multi-enzyme complex has been identified to be a target of Ser/Thr protein kinases (STPKs) of Mycobacterium tuberculosis (MTB), with substrates, including the malonyl-CoA:ACP transacylase (FabD) and the β-ketoacyl-ACP synthases KasA and KasB. These proteins are phosphorylated by various kinases in vitro. The present study links the correlation of FASII pathway with serine threonine protein kinase of MTB. In the preliminary finding, we have shown that mycobacterial protein Rv3080c (PknK) phosphorylates FabD and the knockdown of PknK protein in mycobacteria down regulates FabD expression. This event leads to the differential inhibition of mycobacteria in the presence of isoniazid (INH), as the inhibition of growth of mycobacteria in the presence of INH is enhanced in PknK deficient mycobacteria.

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Year:  2012        PMID： 23180244     DOI： 10.1007/s11010-012-1514-5

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  27 in total

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Authors:  S Ramaswamy; J M Musser
Journal:  Tuber Lung Dis       Date:  1998

2.  The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape.

Authors:  Choong-Min Kang; Derek W Abbott; Sang Tae Park; Christopher C Dascher; Lewis C Cantley; Robert N Husson
Journal:  Genes Dev       Date:  2005-06-28       Impact factor: 11.361

3.  The serine/threonine protein kinase PknI controls the growth of Mycobacterium tuberculosis upon infection.

Authors:  Radha Gopalaswamy; Sujatha Narayanan; Bing Chen; William R Jacobs; Yossef Av-Gay
Journal:  FEMS Microbiol Lett       Date:  2009-04-01       Impact factor: 2.742

4.  Role of Mycobacterium tuberculosis Ser/Thr kinase PknF: implications in glucose transport and cell division.

Authors:  Parampal Deol; Reena Vohra; Adesh Kumar Saini; Amit Singh; Harish Chandra; Puneet Chopra; Taposh K Das; Anil K Tyagi; Yogendra Singh
Journal:  J Bacteriol       Date:  2005-05       Impact factor: 3.490

5.  mymA operon of Mycobacterium tuberculosis: its regulation and importance in the cell envelope.

Authors:  Amit Singh; Shruti Jain; Seema Gupta; Taposh Das; Anil K Tyagi
Journal:  FEMS Microbiol Lett       Date:  2003-10-10       Impact factor: 2.742

6.  Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid.

Authors:  K Mdluli; R A Slayden; Y Zhu; S Ramaswamy; X Pan; D Mead; D D Crane; J M Musser; C E Barry
Journal:  Science       Date:  1998-06-05       Impact factor: 47.728

7.  Effect of isoniazid on the in vivo mycolic acid synthesis, cell growth, and viability of Mycobacterium tuberculosis.

Authors:  K Takayama; L Wang; H L David
Journal:  Antimicrob Agents Chemother       Date:  1972-07       Impact factor: 5.191

8.  Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

Authors:  S T Cole; R Brosch; J Parkhill; T Garnier; C Churcher; D Harris; S V Gordon; K Eiglmeier; S Gas; C E Barry; F Tekaia; K Badcock; D Basham; D Brown; T Chillingworth; R Connor; R Davies; K Devlin; T Feltwell; S Gentles; N Hamlin; S Holroyd; T Hornsby; K Jagels; A Krogh; J McLean; S Moule; L Murphy; K Oliver; J Osborne; M A Quail; M A Rajandream; J Rogers; S Rutter; K Seeger; J Skelton; R Squares; S Squares; J E Sulston; K Taylor; S Whitehead; B G Barrell
Journal:  Nature       Date:  1998-06-11       Impact factor: 49.962

9.  Genetic and biochemical analysis of the serine/threonine protein kinases PknA, PknB, PknG and PknL of Corynebacterium glutamicum: evidence for non-essentiality and for phosphorylation of OdhI and FtsZ by multiple kinases.

Authors:  Christian Schultz; Axel Niebisch; Astrid Schwaiger; Ulrike Viets; Sabine Metzger; Marc Bramkamp; Michael Bott
Journal:  Mol Microbiol       Date:  2009-09-28       Impact factor: 3.501

10.  Downregulation of protein kinase C-alpha enhances intracellular survival of Mycobacteria: role of PknG.

Authors:  Shivendra K Chaurasiya; Kishore K Srivastava
Journal:  BMC Microbiol       Date:  2009-12-24       Impact factor: 3.605
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  4 in total

1.  Identification of Ser/Thr kinase and forkhead associated domains in Mycobacterium ulcerans: characterization of novel association between protein kinase Q and MupFHA.

Authors:  Gunjan Arora; Andaleeb Sajid; Anshika Singhal; Jayadev Joshi; Richa Virmani; Meetu Gupta; Nupur Verma; Abhijit Maji; Richa Misra; Grégory Baronian; Amit K Pandey; Virginie Molle; Yogendra Singh
Journal:  PLoS Negl Trop Dis       Date:  2014-11-20

2.  The impact of combined gene mutations in inhA and ahpC genes on high levels of isoniazid resistance amongst katG non-315 in multidrug-resistant tuberculosis isolates from China.

Authors:  Liguo Liu; Fengting Jiang; Lihong Chen; Bing Zhao; Jie Dong; Lilian Sun; Yafang Zhu; Bo Liu; Yang Zhou; Jian Yang; Yanlin Zhao; Qi Jin; Xiaobing Zhang
Journal:  Emerg Microbes Infect       Date:  2018-11-16       Impact factor: 7.163

3.  In Silico Drug Discovery Strategies Identified ADMET Properties of Decoquinate RMB041 and Its Potential Drug Targets against Mycobacterium tuberculosis.

Authors:  Kirsten E Knoll; Mietha M van der Walt; Du Toit Loots
Journal:  Microbiol Spectr       Date:  2022-03-30

4.  Mycobacterium tuberculosis PknK Substrate Profiling Reveals Essential Transcription Terminator Protein Rho and Two-Component Response Regulators PrrA and MtrA as Novel Targets for Phosphorylation.

Authors:  Vandana Malhotra; Blessing P Okon; Akash T Satsangi; Sumana Das; Uchenna Watson Waturuocha; Atul Vashist; Josephine E Clark-Curtiss; Deepak Kumar Saini
Journal:  Microbiol Spectr       Date:  2022-04-11
  4 in total

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