Literature DB >> 2317960

Inhibition of lung colonization of mouse colon 26 adenocarcinoma by recombinant mouse interferon beta through a modification of platelet function.

T Tsuruo1, H Saito, M Watanabe, Y Sugimoto, T Yamori, T Oh-Hara.   

Abstract

Recombinant murine interferon beta (MuIFN-beta) given i.v. efficiently inhibited both pulmonary arrest and formation of lung colonies of NL-17, a highly metastatic variant of mouse colon adenocarcinoma 26. NL-17 was rather resistant to MuIFN-beta in vitro and was highly resistant to natural killer cells of mice even though they were treated in vivo with MuIFN-beta. Platelets isolated from MuIFN-beta-treated mice showed reduced aggregating activity induced by NL-17. Since lung colonization by NL-17 is influenced by platelet aggregation, the inhibition of colonization by MuIFN-beta could be partly mediated through modification of platelet function in vivo. The effect of MuIFN-beta on platelet function and its subsequent inhibition of lung colony formation give new insights into the action of recombinant MuIFN-beta.

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Year:  1990        PMID： 2317960     DOI： 10.1007/bf00117793

Source DB:  PubMed          Journal:  Clin Exp Metastasis        ISSN： 0262-0898            Impact factor:   5.150


  23 in total

Review 1.  Interferons with special emphasis on the immune system.

Authors:  R M Friedman; S N Vogel
Journal:  Adv Immunol       Date:  1983       Impact factor: 3.543

2.  Characterization of metastatic clones derived from a metastatic variant of mouse colon adenocarcinoma 26.

Authors:  T Tsuruo; T Yamori; K Naganuma; S Tsukagoshi; Y Sakurai
Journal:  Cancer Res       Date:  1983-11       Impact factor: 12.701

3.  Inhibition of growth of B16 murine malignant melanoma by exogenous interferon.

Authors:  R S Bart; N R Porzio; A W Kopf; J T Vilcek; E H Cheng; Y Farcet
Journal:  Cancer Res       Date:  1980-03       Impact factor: 12.701

4.  Role of NK cells in tumour growth and metastasis in beige mice.

Authors:  J E Talmadge; K M Meyers; D J Prieur; J R Starkey
Journal:  Nature       Date:  1980-04-17       Impact factor: 49.962

5.  Studies on the antitumor activities of pyrimidinone-interferon inducers. I. Effect against artificial and spontaneous lung metastases of murine tumors.

Authors:  L Milas; E M Hersh; D A Stringfellow; N Hunter
Journal:  J Natl Cancer Inst       Date:  1982-01       Impact factor: 13.506

6.  Antitumor and antimetastatic activities of human recombinant interferon alpha A/D.

Authors:  J Nishimura; K Mitsui; T Ishikawa; Y Tanaka; R Yamamoto; Y Suhara; H Ishitsuka
Journal:  Clin Exp Metastasis       Date:  1985 Oct-Dec       Impact factor: 5.150

7.  Transplantability and sensitivity to natural killer cells of aclarubicin-resistant murine lymphoma.

Authors:  Y Sugimoto; Y Hirakawa; N Tanaka; M Tahara; I Sato; T Nishimura; H Suzuki; N Tanaka
Journal:  Cancer Res       Date:  1986-11       Impact factor: 12.701

8.  Acquisition of metastatic ability in hybridomas between two low metastatic clones of murine colon adenocarcinoma 26 defective in either platelet-aggregating activity or in vivo growth potential.

Authors:  Y Sugimoto; T Oh-hara; M Watanabe; H Saito; T Yamori; T Tsuruo
Journal:  Cancer Res       Date:  1987-08-15       Impact factor: 12.701

9.  Role of laminin in the attachment and metastasis of murine tumor cells.

Authors:  V P Terranova; L A Liotta; R G Russo; G R Martin
Journal:  Cancer Res       Date:  1982-06       Impact factor: 12.701

10.  Role of natural killer cells in the destruction of circulating tumor emboli.

Authors:  N Hanna; I J Fidler
Journal:  J Natl Cancer Inst       Date:  1980-10       Impact factor: 13.506
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