Metastatic abilities of murine sarcomas and carcinomas. II. Relationship to cell volume and DNA index.

The cell volume and DNA content were determined in 12 murine tumors and correlated with the ability of these tumors to metastasize spontaneously or to form lung nodules when injected i.v. The cell volume significantly correlated with spontaneous metastatic potential of investigated tumors (r = 0.683; 0.02 less than P less than 0.05) but not with the ability of tumor cells to form artificial metastasis. The DNA index significantly correlated with both spontaneous metastasis (r = 0.594; 0.02 less than P less than 0.05), and lung colonization (r = 0.631; 0.02 less than P less than 0.05). The DNA index barely correlated with the cell volume (r = 0.564; P = 0.10).