Literature DB >> 23179567

Subchondral bone and osteoarthritis: biological and cellular aspects.

Y Henrotin1, L Pesesse, C Sanchez.   

Abstract

The subchondral bone is involved in the pathophysiology of osteoarthritis (OA), both by biochemical and mechanical pathways. Overloaded OA subchondral bone osteoblasts express a pro-angiogenic and pro-inflammatory phenotype which contributes to explain the structural changes (sclerosis and bone marrow lesion) visible in OA subchondral bone. Further, microfractures and conjonctivo-vascular structures constitute exchange routes between bone and the overlying cartilage for mediators produced by osteoblasts. This narrative review describes these physiopathological mechanisms and identifies possible therapeutic targets for pharmacological modalities.

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Year:  2012        PMID： 23179567     DOI： 10.1007/s00198-012-2162-z

Source DB:  PubMed          Journal:  Osteoporos Int        ISSN： 0937-941X            Impact factor:   4.507


  38 in total

1.  Phenotypic expression of osteoblast collagen in osteoarthritic bone: production of type I homotrimer.

Authors:  Allen J Bailey; Trevor J Sims; Lynda Knott
Journal:  Int J Biochem Cell Biol       Date:  2002-02       Impact factor: 5.085

2.  Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis.

Authors:  B Y Chan; E S Fuller; A K Russell; S M Smith; M M Smith; M T Jackson; M A Cake; R A Read; J F Bateman; P N Sambrook; C B Little
Journal:  Osteoarthritis Cartilage       Date:  2011-05-12       Impact factor: 6.576

3.  Increase in bone marrow lesions associated with cartilage loss: a longitudinal magnetic resonance imaging study of knee osteoarthritis.

Authors:  David J Hunter; Yuqing Zhang; Jingbo Niu; Joyce Goggins; Shreyasee Amin; Michael P LaValley; Ali Guermazi; Harry Genant; Daniel Gale; David T Felson
Journal:  Arthritis Rheum       Date:  2006-05

4.  Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts.

Authors:  Steeve Kwan Tat; Jean-Pierre Pelletier; François Mineau; Judith Caron; Johanne Martel-Pelletier
Journal:  Bone       Date:  2011-06-12       Impact factor: 4.398

5.  Partial chondroprotective effect of zoledronate in a rabbit model of inflammatory arthritis.

Authors:  N V Podworny; R A Kandel; R C Renlund; M D Grynpas
Journal:  J Rheumatol       Date:  1999-09       Impact factor: 4.666

6.  Subchondral bone osteoblasts induce phenotypic changes in human osteoarthritic chondrocytes.

Authors:  C Sanchez; M A Deberg; N Piccardi; P Msika; J-Y L Reginster; Y E Henrotin
Journal:  Osteoarthritis Cartilage       Date:  2005-09-13       Impact factor: 6.576

7.  Abnormal regulation of urokinase plasminogen activator by insulin-like growth factor 1 in human osteoarthritic subchondral osteoblasts.

Authors:  G Hilal; J Martel-Pelletier; J P Pelletier; N Duval; D Lajeunesse
Journal:  Arthritis Rheum       Date:  1999-10

8.  Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease.

Authors:  B W Strassle; L Mark; L Leventhal; M J Piesla; X Jian Li; J D Kennedy; S S Glasson; G T Whiteside
Journal:  Osteoarthritis Cartilage       Date:  2010-07-13       Impact factor: 6.576

9.  Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone.

Authors:  Christelle Sanchez; Michelle A Deberg; Akeila Bellahcène; Vincent Castronovo; Philippe Msika; J P Delcour; J M Crielaard; Yves E Henrotin
Journal:  Arthritis Rheum       Date:  2008-02

10.  Osteoblasts derived from osteophytes produce interleukin-6, interleukin-8, and matrix metalloproteinase-13 in osteoarthritis.

Authors:  Kei Sakao; Kenji A Takahashi; Yuji Arai; Masazumi Saito; Kuniaki Honjo; Nobuyuki Hiraoka; Hidetsugu Asada; Masaharu Shin-Ya; Jiro Imanishi; Osam Mazda; Toshikazu Kubo
Journal:  J Bone Miner Metab       Date:  2009-04-01       Impact factor: 2.626
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  25 in total

1.  Effect of open wedge high tibial osteotomy on the lateral tibiofemoral compartment in sheep. Part III: analysis of the microstructure of the subchondral bone and correlations with the articular cartilage and meniscus.

Authors:  Raphaela Ziegler; Lars Goebel; Roland Seidel; Magali Cucchiarini; Dietrich Pape; Henning Madry
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2014-06-14       Impact factor: 4.342

2.  Alpha C-telopeptide of type I collagen is associated with subchondral bone turnover and predicts progression of joint space narrowing and osteophytes in osteoarthritis.

Authors:  Janet L Huebner; Anne C Bay-Jensen; Kim M Huffman; Yi He; Diana J Leeming; Gary E McDaniel; Morten A Karsdal; Virginia B Kraus
Journal:  Arthritis Rheumatol       Date:  2014-09       Impact factor: 10.995

3.  Zoledronic acid does not slow spinal radiographic progression of osteoarthritis in postmenopausal women with osteoporosis and radiographic osteoarthritis.

Authors:  L V Host; H I Keen; L L Laslett; D M Black; G Jones
Journal:  Ther Adv Musculoskelet Dis       Date:  2022-07-04       Impact factor: 3.625

4.  MAGNETIC RESONANCE IMAGING SCORING OF AN EXPERIMENTAL MODEL OF POST-TRAUMATIC OSTEOARTHRITIS IN THE EQUINE CARPUS.

Authors:  Andrew D Smith; Alison J Morton; Matthew D Winter; Patrick T Colahan; Steve Ghivizzani; Murray P Brown; Jorge A Hernandez; David M Nickerson
Journal:  Vet Radiol Ultrasound       Date:  2016-05-19       Impact factor: 1.363

Review 5.  Three-dimensional osteogenic and chondrogenic systems to model osteochondral physiology and degenerative joint diseases.

Authors:  Peter G Alexander; Riccardo Gottardi; Hang Lin; Thomas P Lozito; Rocky S Tuan
Journal:  Exp Biol Med (Maywood)       Date:  2014-07-03

6.  Effects of a progressive aquatic resistance exercise program on the biochemical composition and morphology of cartilage in women with mild knee osteoarthritis: protocol for a randomised controlled trial.

Authors:  Benjamin Waller; Matti Munukka; Juhani Multanen; Timo Rantalainen; Tapani Pöyhönen; Miika T Nieminen; Ilkka Kiviranta; Hannu Kautiainen; Harri Selänne; Joost Dekker; Sarianna Sipilä; Urho M Kujala; Arja Häkkinen; Ari Heinonen
Journal:  BMC Musculoskelet Disord       Date:  2013-03-07       Impact factor: 2.362

7.  OsteoRheumatology: a new discipline?

Authors:  Marta Favero; Andrea Giusti; Piet Geusens; Steven R Goldring; Willem Lems; Georg Schett; Gerolamo Bianchi
Journal:  RMD Open       Date:  2015-08-15

8.  Genetic analysis of high bone mass cases from the BARCOS cohort of Spanish postmenopausal women.

Authors:  Patricia Sarrión; Leonardo Mellibovsky; Roser Urreizti; Sergi Civit; Neus Cols; Natàlia García-Giralt; Guy Yoskovitz; Alvaro Aranguren; Jorge Malouf; Silvana Di Gregorio; Luís Del Río; Roberto Güerri; Xavier Nogués; Adolfo Díez-Pérez; Daniel Grinberg; Susana Balcells
Journal:  PLoS One       Date:  2014-04-15       Impact factor: 3.240

Review 9.  Current perspectives in stem cell research for knee cartilage repair.

Authors:  Patrick Orth; Ana Rey-Rico; Jagadeesh K Venkatesan; Henning Madry; Magali Cucchiarini
Journal:  Stem Cells Cloning       Date:  2014-01-16

10.  Stem cell-based microphysiological osteochondral system to model tissue response to interleukin-1β.

Authors:  Hang Lin; Thomas P Lozito; Peter G Alexander; Riccardo Gottardi; Rocky S Tuan
Journal:  Mol Pharm       Date:  2014-06-02       Impact factor: 4.939
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