Literature DB >> 23179316

Saw palmetto ethanol extract inhibits adipocyte differentiation.

Nicole Villaverde1, Adriana Galvis, Adriana Marcano, Horacio A Priestap, Bradley C Bennett, M Alejandro Barbieri.   

Abstract

The fruits of saw palmetto have been used for the treatment of a variety of urinary and reproductive system problems. In this study we investigated whether the fruit extracts affect in vitro adipogenesis. Saw palmetto ethanol extract inhibited the lipid droplet accumulation by induction media in a dose-dependent manner, and it also attenuated the protein expressions of C-EBPα and PPARγ. Phosphorylation of Erk1/2 and Akt1 were also decreased by saw palmetto ethanol extract. This report suggests that saw palmetto extracts selectively affect the adipocyte differentiation through the modulation of several key factors that play a critical role during adipogenesis.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 23179316     DOI： 10.1007/s11418-012-0723-2

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  35 in total

Review 1.  A scientific basis for the therapeutic effects of Pygeum africanum and Serenoa repens.

Authors:  R M Levin; A K Das
Journal:  Urol Res       Date:  2000-06

2.  [Anti-inflammatory activity of sabal fruit extracts prepared with supercritical carbon dioxide. In vitro antagonists of cyclooxygenase and 5-lipoxygenase metabolism].

Authors:  W Breu; M Hagenlocher; K Redl; G Tittel; F Stadler; H Wagner
Journal:  Arzneimittelforschung       Date:  1992-04

3.  Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia, and hyperinsulinemia: increase in serum ghrelin levels.

Authors:  Michael G Dube; Elena Beretta; Harveen Dhillon; Naohiko Ueno; Pushpa S Kalra; Satya P Kalra
Journal:  Diabetes       Date:  2002-06       Impact factor: 9.461

4.  Extracellular matrix mineralization and osteoblast gene expression by human adipose tissue-derived stromal cells.

Authors:  Y D Halvorsen; D Franklin; A L Bond; D C Hitt; C Auchter; A L Boskey; E P Paschalis; W O Wilkison; J M Gimble
Journal:  Tissue Eng       Date:  2001-12

5.  Adipose tissue cellularity in human obesity.

Authors:  J Hirsch; B Batchelor
Journal:  Clin Endocrinol Metab       Date:  1976-07

6.  Inhibition of steroid 5 alpha-reductase by specific aliphatic unsaturated fatty acids.

Authors:  T Liang; S Liao
Journal:  Biochem J       Date:  1992-07-15       Impact factor: 3.857

7.  Effects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissue.

Authors:  Allain Amador Bueno; Lila Missae Oyama; Cristiane de Oliveira; Luciana Pelegrini Pisani; Eliane Beraldi Ribeiro; Vera Lucia Flor Silveira; Cláudia Maria Oller do Nascimento
Journal:  Pflugers Arch       Date:  2007-08-24       Impact factor: 3.657

8.  Muscarinic and alpha 1-adrenergic receptor binding characteristics of saw palmetto extract in rat lower urinary tract.

Authors:  Mayumi Suzuki; Tomomi Oki; Tomomi Sugiyama; Keizo Umegaki; Shinya Uchida; Shizuo Yamada
Journal:  Urology       Date:  2007-06       Impact factor: 2.649

9.  Inhibition of androgen metabolism and binding by a liposterolic extract of "Serenoa repens B" in human foreskin fibroblasts.

Authors:  C Sultan; A Terraza; C Devillier; E Carilla; M Briley; C Loire; B Descomps
Journal:  J Steroid Biochem       Date:  1984-01       Impact factor: 4.292

10.  Development of saw palmetto (Serenoa repens) fruit and extract standard reference materials.

Authors:  Michele M Schantz; Mary Bedner; Stephen E Long; John L Molloy; Karen E Murphy; Barbara J Porter; Karsten Putzbach; Catherine A Rimmer; Lane C Sander; Katherine E Sharpless; Jeanice B Thomas; Stephen A Wise; Laura J Wood; James H Yen; Takashi Yarita; Agnes NguyenPho; Wendy R Sorenson; Joseph M Betz
Journal:  Anal Bioanal Chem       Date:  2008-08-02       Impact factor: 4.142
View more
  1 in total

1.  New Natural Pigment Fraction Isolated from Saw Palmetto: Potential for Adjuvant Therapy of Hepatocellular Carcinoma.

Authors:  Hor-Yue Tan; Ning Wang; Masao Takahashi; Yigang Feng; Hongyun Li; Yibin Feng
Journal:  Int J Mol Sci       Date:  2016-08-05       Impact factor: 5.923
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.