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Literature DB >> 23178848

Structural mechanisms of the agrin-LRP4-MuSK signaling pathway in neuromuscular junction differentiation.

Abstract

The neuromuscular junction (NMJ) is the most extensively studied model of neuronal synaptogenesis. Acetylcholine receptor (AChR) clustering on the postsynaptic membrane is a cardinal event in the differentiation of NMJs. AChR clustering and postsynaptic differentiation is orchestrated by sophisticated interactions among three proteins: the neuron-secreted proteoglycan agrin, the co-receptor LRP4, and the muscle-specific receptor tyrosine kinase MuSK. LRP4 and MuSK act as scaffolds for multiple binding partners, resulting in a complex and dynamic network of interacting proteins that is required for AChR clustering. In this review, we discuss the structural basis for NMJ postsynaptic differentiation mediated by the agrin-LRP4-MuSK signaling pathway.

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Year: 2012 PMID： 23178848 PMCID： PMC4627850 DOI： 10.1007/s00018-012-1209-9

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

106 in total

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Journal: Neuron Date: 2001-05 Impact factor: 17.173

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Authors: Chao-Neng Tseng; Lili Zhang; Michael Cascio; Zuo-Zhong Wang
Journal: J Biol Chem Date: 2003-03-05 Impact factor: 5.157

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Journal: Cell Date: 1996-04-19 Impact factor: 41.582

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Journal: J Biol Chem Date: 1995-06-23 Impact factor: 5.157

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Authors: Dominique Simon-Chazottes; Sylvie Tutois; Michael Kuehn; Martin Evans; Franck Bourgade; Sue Cook; Muriel T Davisson; Jean-Louis Guénet
Journal: Genomics Date: 2006-03-06 Impact factor: 5.736

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Authors: J T Campanelli; G G Gayer; R H Scheller
Journal: Development Date: 1996-05 Impact factor: 6.868

10. Distinct domains of MuSK mediate its abilities to induce and to associate with postsynaptic specializations.

Authors: H Zhou; D J Glass; G D Yancopoulos; J R Sanes
Journal: J Cell Biol Date: 1999-09-06 Impact factor: 10.539

27 in total

1. Non-synaptic roles of acetylcholinesterase and agrin.

Authors: Katarina Gros; Giulia Parato; Sergej Pirkmajer; Katarina Mis; Matej Podbregar; Zoran Grubic; Paola Lorenzon; Tomaz Mars
Journal: J Mol Neurosci Date: 2013-12-11 Impact factor: 3.444

2. [Sepsis impairs aggregation of nicotinic acetylcholine receptors on murine skeletal muscle cell membranes by inhibiting AKT/GSK3β phosphorylation].

Authors: Tianmei Li; Li Liu; Xiaobin Wang
Journal: Nan Fang Yi Ke Da Xue Xue Bao Date: 2019-11-30

3. Collagen 18 and agrin are secreted by neural crest cells to remodel their microenvironment and regulate their migration during enteric nervous system development.

Authors: Nandor Nagy; Csilla Barad; Ryo Hotta; Sukhada Bhave; Emily Arciero; David Dora; Allan M Goldstein
Journal: Development Date: 2018-05-08 Impact factor: 6.868

4. Pathogenic effects of agrin V1727F mutation are isoform specific and decrease its expression and affinity for HSPGs and LRP4.

Authors: John B Rudell; Ricardo A Maselli; Vladimir Yarov-Yarovoy; Michael J Ferns
Journal: Hum Mol Genet Date: 2019-08-15 Impact factor: 6.150