Literature DB >> 23178814

Identifying molecular drivers of gastric cancer through next-generation sequencing.

Han Liang1, Yon Hui Kim.   

Abstract

Gastric cancer is the second most common cause of cancer-related death in the world, representing a major global health issue. The high mortality rate is largely due to the lack of effective medical treatment for advanced stages of this disease. Recently next-generation sequencing (NGS) technology has become a revolutionary tool for cancer research, and several NGS studies in gastric cancer have been published. Here we review the insights gained from these studies regarding how use NGS to elucidate the molecular basis of gastric cancer and identify potential therapeutic targets. We also discuss the challenges and future directions of such efforts. Published by Elsevier Ireland Ltd.

Entities:  

Keywords:  Gastric cancer; Gene fusion; Next-generation sequencing; RNA sequencing; Somatic mutation; Therapeutic target

Mesh：

Substances：

Year:  2012        PMID： 23178814      PMCID： PMC3873853          DOI： 10.1016/j.canlet.2012.11.029

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  47 in total

1.  Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing.

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Journal:  Cancer Res       Date:  2010-11-19       Impact factor: 12.701

2.  AMPKα modulation in cancer progression: multilayer integrative analysis of the whole transcriptome in Asian gastric cancer.

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Journal:  Cancer Res       Date:  2012-03-20       Impact factor: 12.701

3.  AMPKα2 Suppresses Murine Embryonic Fibroblast Transformation and Tumorigenesis.

Authors:  Kathryn N Phoenix; Charan V Devarakonda; Melissa M Fox; Laura E Stevens; Kevin P Claffey
Journal:  Genes Cancer       Date:  2012-01

Review 4.  Helicobacter pylori infection generates genetic instability in gastric cells.

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Journal:  Biochim Biophys Acta       Date:  2010-02-01

Review 5.  Esophagogastric cancer: targeted agents.

Authors:  Geoffrey Y Ku; David H Ilson
Journal:  Cancer Treat Rev       Date:  2010-02-01       Impact factor: 12.111

6.  Human mutation rate associated with DNA replication timing.

Authors:  John A Stamatoyannopoulos; Ivan Adzhubei; Robert E Thurman; Gregory V Kryukov; Sergei M Mirkin; Shamil R Sunyaev
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Review 7.  RNA-Seq: a revolutionary tool for transcriptomics.

Authors:  Zhong Wang; Mark Gerstein; Michael Snyder
Journal:  Nat Rev Genet       Date:  2009-01       Impact factor: 53.242

Review 8.  Gastric cancer in the era of molecularly targeted agents: current drug development strategies.

Authors:  Hendrik-Tobias Arkenau
Journal:  J Cancer Res Clin Oncol       Date:  2009-04-11       Impact factor: 4.553

9.  HER2 expression in gastric cancer: Rare, heterogeneous and of no prognostic value - conclusions from 924 cases of two independent series.

Authors:  Heike Grabsch; Shivan Sivakumar; Sally Gray; Helmut E Gabbert; Wolfram Müller
Journal:  Cell Oncol       Date:  2010       Impact factor: 6.730

Review 10.  Application of next-generation sequencing in clinical oncology to advance personalized treatment of cancer.

Authors:  Yan-Fang Guan; Gai-Rui Li; Rong-Jiao Wang; Yu-Ting Yi; Ling Yang; Dan Jiang; Xiao-Ping Zhang; Yin Peng
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  26 in total

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Authors:  Renu Verma; Prakash C Sharma
Journal:  Am J Cancer Res       Date:  2018-02-01       Impact factor: 6.166

2.  Recombinant adenovirus expressing hIFN-λ1 inhibits gastric adenocarcinoma cell line SGC-7901 proliferation.

Authors:  Xuefeng Bu; Mubin Wang; Jie Zhang; Jun Liu; Lijuan Jia; Bing Liang; Yulan Yan
Journal:  Oncol Lett       Date:  2015-11-06       Impact factor: 2.967

Review 3.  Recent advances in the molecular diagnostics of gastric cancer.

Authors:  Mitsuro Kanda; Yasuhiro Kodera
Journal:  World J Gastroenterol       Date:  2015-09-14       Impact factor: 5.742

4.  Docetaxel, oxaliplatin, and capecitabine combination chemotherapy for metastatic gastric cancer.

Authors:  Luigi Di Lauro; Patrizia Vici; Franca Belli; Silverio Tomao; Silvia Ileana Fattoruso; Maria Grazia Arena; Laura Pizzuti; Diana Giannarelli; Giancarlo Paoletti; Maddalena Barba; Domenico Sergi; Marcello Maugeri-Saccà
Journal:  Gastric Cancer       Date:  2013-12-08       Impact factor: 7.370

Review 5.  An updated review of gastric cancer in the next-generation sequencing era: insights from bench to bedside and vice versa.

Authors:  Hiroyuki Yamamoto; Yoshiyuki Watanabe; Tadateru Maehata; Ryo Morita; Yoshihito Yoshida; Ritsuko Oikawa; Shinya Ishigooka; Shun-Ichiro Ozawa; Yasumasa Matsuo; Kosuke Hosoya; Masaki Yamashita; Hiroaki Taniguchi; Katsuhiko Nosho; Hiromu Suzuki; Hiroshi Yasuda; Yasuhisa Shinomura; Fumio Itoh
Journal:  World J Gastroenterol       Date:  2014-04-14       Impact factor: 5.742

6.  MicroRNA-29c mediates initiation of gastric carcinogenesis by directly targeting ITGB1.

Authors:  Tae-Su Han; Keun Hur; Guorong Xu; Boram Choi; Yoshinaga Okugawa; Yuji Toiyama; Hiroko Oshima; Masanobu Oshima; Hyuk-Joon Lee; V Narry Kim; Aaron N Chang; Ajay Goel; Han-Kwang Yang
Journal:  Gut       Date:  2014-05-28       Impact factor: 23.059

Review 7.  Advances in molecular biomarkers for gastric cancer: miRNAs as emerging novel cancer markers.

Authors:  Hua-Hsi Wu; Wen-chang Lin; Kuo-Wang Tsai
Journal:  Expert Rev Mol Med       Date:  2014-01-23       Impact factor: 5.600

8.  FOLFIRI as a second-line therapy in patients with docetaxel-pretreated gastric cancer: a historical cohort.

Authors:  Marcello Maugeri-Saccà; Laura Pizzuti; Domenico Sergi; Maddalena Barba; Franca Belli; Silvia Fattoruso; Diana Giannarelli; Antonella Amodio; Sara Boggia; Patrizia Vici; Luigi Di Lauro
Journal:  J Exp Clin Cancer Res       Date:  2013-09-17

9.  Clinical massively parallel next-generation sequencing analysis of 409 cancer-related genes for mutations and copy number variations in solid tumours.

Authors:  R R Singh; K P Patel; M J Routbort; K Aldape; X Lu; J Manekia; R Abraham; N G Reddy; B A Barkoh; J Veliyathu; L J Medeiros; R Luthra
Journal:  Br J Cancer       Date:  2014-10-14       Impact factor: 7.640

10.  Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.

Authors:  Jinfeng Liu; Mark McCleland; Eric W Stawiski; Florian Gnad; Oleg Mayba; Peter M Haverty; Steffen Durinck; Ying-Jiun Chen; Christiaan Klijn; Suchit Jhunjhunwala; Michael Lawrence; Hanbin Liu; Yinan Wan; Vivek Chopra; Murat B Yaylaoglu; Wenlin Yuan; Connie Ha; Houston N Gilbert; Jens Reeder; Gregoire Pau; Jeremy Stinson; Howard M Stern; Gerard Manning; Thomas D Wu; Richard M Neve; Frederic J de Sauvage; Zora Modrusan; Somasekar Seshagiri; Ron Firestein; Zemin Zhang
Journal:  Nat Commun       Date:  2014-05-08       Impact factor: 14.919
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