| Literature DB >> 2317837 |
M N Lombard1, D Sotty, J Wdzieczak-Bakala, M Lenfant.
Abstract
The synthetic molecule N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP), corresponding to the low molecular weight inhibitory factor preventing in vivo haematopoietic stem cell (CFU-S) entry into DNA synthesis, was tested in two heterologous systems in vivo: adult regenerating rat liver and 10-day-old rat hepatocytes synchronized by an irritating trigger. In both systems, it was shown that doses of 2-8 micrograms kg-1 of tetrapeptide inhibited 50-70% of the hepatocyte G1-S transitions.Entities:
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Year: 1990 PMID： 2317837 DOI： 10.1111/j.1365-2184.1990.tb01336.x
Source DB: PubMed Journal: Cell Tissue Kinet ISSN： 0008-8730