| Literature DB >> 23177783 |
John M Fevig1, Jianxin Feng, Karen A Rossi, Keith J Miller, Ginger Wu, Chen-Pin Hung, Thao Ung, Sarah E Malmstrom, Ge Zhang, William J Keim, Mary Jane Cullen, Kenneth W Rohrbach, Qinling Qu, Jinping Gan, Mary Ann Pelleymounter, Jeffrey A Robl.
Abstract
A series of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones is described, several examples of which exhibit potent 5-HT(2C) agonism with excellent selectivity over the closely related 5-HT(2A) and 5-HT(2B) receptors. Compounds such as 38 and 44 were shown to be effective in reducing food intake in an acute rat feeding model.Entities:
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Year: 2012 PMID： 23177783 DOI： 10.1016/j.bmcl.2012.10.091
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823