PURPOSE: To study the prognosis of the different types of uveal melanoma recurrences treated by proton beam therapy (PBT). METHODS AND MATERIALS: This retrospective study analyzed 61 cases of uveal melanoma local recurrences on a total of 1102 patients treated by PBT between June 1991 and December 2010. Survival rates have been determined by using Kaplan-Meier curves. Prognostic factors have been evaluated by using log-rank test or Cox model. RESULTS: Our local recurrence rate was 6.1% at 5 years. These recurrences were divided into 25 patients with marginal recurrences, 18 global recurrences, 12 distant recurrences, and 6 extrascleral extensions. Five factors have been identified as statistically significant risk factors of local recurrence in the univariate analysis: large tumoral diameter, small tumoral volume, low ratio of tumoral volume over eyeball volume, iris root involvement, and safety margin inferior to 1 mm. In the local recurrence-free population, the overall survival rate was 68.7% at 10 years and the specific survival rate was 83.6% at 10 years. In the local recurrence population, the overall survival rate was 43.1% at 10 years and the specific survival rate was 55% at 10 years. The multivariate analysis of death risk factors has shown a better prognosis for marginal recurrences. CONCLUSION: Survival rate of marginal recurrences is superior to that of the other recurrences. The type of recurrence is a clinical prognostic value to take into account. The influence of local recurrence retreatment by proton beam therapy should be evaluated by novel studies.
PURPOSE: To study the prognosis of the different types of uveal melanoma recurrences treated by proton beam therapy (PBT). METHODS AND MATERIALS: This retrospective study analyzed 61 cases of uveal melanoma local recurrences on a total of 1102 patients treated by PBT between June 1991 and December 2010. Survival rates have been determined by using Kaplan-Meier curves. Prognostic factors have been evaluated by using log-rank test or Cox model. RESULTS: Our local recurrence rate was 6.1% at 5 years. These recurrences were divided into 25 patients with marginal recurrences, 18 global recurrences, 12 distant recurrences, and 6 extrascleral extensions. Five factors have been identified as statistically significant risk factors of local recurrence in the univariate analysis: large tumoral diameter, small tumoral volume, low ratio of tumoral volume over eyeball volume, iris root involvement, and safety margin inferior to 1 mm. In the local recurrence-free population, the overall survival rate was 68.7% at 10 years and the specific survival rate was 83.6% at 10 years. In the local recurrence population, the overall survival rate was 43.1% at 10 years and the specific survival rate was 55% at 10 years. The multivariate analysis of death risk factors has shown a better prognosis for marginal recurrences. CONCLUSION: Survival rate of marginal recurrences is superior to that of the other recurrences. The type of recurrence is a clinical prognostic value to take into account. The influence of local recurrence retreatment by proton beam therapy should be evaluated by novel studies.
Authors: Nikolas S Hopkins; Ilyse S Kornblau; Christopher E Montes-Sabino; Alan Boom; Matthew W Wilson Journal: Am J Ophthalmol Case Rep Date: 2022-10-07
Authors: Benjamin A King; Caroline Awh; Brad T Gao; Jiajing Wang; Mehmet Kocak; Vanessa M Morales-Tirado; Matthew T Ballo; Matthew W Wilson Journal: Ocul Oncol Pathol Date: 2019-01-10
Authors: Youn Joo Choi; Tae Wan Kim; Suzy Kim; Hokyung Choung; Min Joung Lee; Namju Kim; Sang In Khwarg; Young Suk Yu Journal: J Korean Med Sci Date: 2018-04-16 Impact factor: 2.153
Authors: Luca Tagliaferri; Monica Maria Pagliara; Bruno Fionda; Andrea Scupola; Luigi Azario; Maria Grazia Sammarco; Rosa Autorino; Valentina Lancellotta; Silvia Cammelli; Carmela Grazia Caputo; Rafael Martinez-Monge; György Kovács; Maria Antonietta Gambacorta; Vincenzo Valentini; Maria Antonietta Blasi Journal: J Contemp Brachytherapy Date: 2019-02-28
Authors: E Fleury; P Trnková; E Erdal; M Hassan; B Stoel; M Jaarma-Coes; G Luyten; J Herault; A Webb; J-W Beenakker; J-P Pignol; M Hoogeman Journal: Med Phys Date: 2021-01-17 Impact factor: 4.071