OBJECTIVES: To determine the relationship between depressive symptoms after hospitalization and survival and functional outcomes. DESIGN: Secondary analysis of a prospective cohort study. SETTING: General medical service of two urban, teaching hospitals in Ohio. PARTICIPANTS: Hospitalized individuals aged 70 and older. MEASUREMENTS: Ten depressive symptoms, instrumental activities of daily living (IADLs), and basic activities of daily living (ADLs) were measured at hospital discharge and 1, 3, 6, and 12 months later. Participant-specific changes in depressive symptoms (slopes) were determined using all data points. Four groups were also defined according to number of depressive symptoms (≤3 symptoms, low; 4-10 symptoms, high) at discharge and follow-up: low-low, low-high, high-low, and high-high. Mortality was measured 3, 6, and 12 months after hospital discharge. RESULTS: Participant-specific discharge depressive symptoms and change in depressive symptoms over time (slopes) were associated (P < .05) with functional and mortality outcomes. At 1 year, more participants in the low-low depressive symptom group (49%) were alive and independent in IADLs and ADLs than in the low-high group (37%, P = .02), and more participants in the high-low group (39%) were alive and independent in IADLs and ADLs than in the high-high group (19%, P < .001). CONCLUSION: Number of depressive symptoms and change in number of depressive symptoms during the year after discharge were associated with functional and mortality outcomes in hospitalized older adults. Fewer participants with persistently high or increasing depressive symptoms after hospitalization were alive and functionally independent 1 year later than participants with decreasing or persistently low symptoms, respectively.
OBJECTIVES: To determine the relationship between depressive symptoms after hospitalization and survival and functional outcomes. DESIGN: Secondary analysis of a prospective cohort study. SETTING: General medical service of two urban, teaching hospitals in Ohio. PARTICIPANTS: Hospitalized individuals aged 70 and older. MEASUREMENTS: Ten depressive symptoms, instrumental activities of daily living (IADLs), and basic activities of daily living (ADLs) were measured at hospital discharge and 1, 3, 6, and 12 months later. Participant-specific changes in depressive symptoms (slopes) were determined using all data points. Four groups were also defined according to number of depressive symptoms (≤3 symptoms, low; 4-10 symptoms, high) at discharge and follow-up: low-low, low-high, high-low, and high-high. Mortality was measured 3, 6, and 12 months after hospital discharge. RESULTS:Participant-specific discharge depressive symptoms and change in depressive symptoms over time (slopes) were associated (P < .05) with functional and mortality outcomes. At 1 year, more participants in the low-low depressive symptom group (49%) were alive and independent in IADLs and ADLs than in the low-high group (37%, P = .02), and more participants in the high-low group (39%) were alive and independent in IADLs and ADLs than in the high-high group (19%, P < .001). CONCLUSION: Number of depressive symptoms and change in number of depressive symptoms during the year after discharge were associated with functional and mortality outcomes in hospitalized older adults. Fewer participants with persistently high or increasing depressive symptoms after hospitalization were alive and functionally independent 1 year later than participants with decreasing or persistently low symptoms, respectively.
Authors: L C Walter; R J Brand; S R Counsell; R M Palmer; C S Landefeld; R H Fortinsky; K E Covinsky Journal: JAMA Date: 2001-06-20 Impact factor: 56.272
Authors: W Jiang; J Alexander; E Christopher; M Kuchibhatla; L H Gaulden; M S Cuffe; M A Blazing; C Davenport; R M Califf; R R Krishnan; C M O'Connor Journal: Arch Intern Med Date: 2001 Aug 13-27
Authors: Heidi L Wald; Luci K Leykum; Melissa L P Mattison; Eduard E Vasilevskis; David O Meltzer Journal: J Hosp Med Date: 2015-04-16 Impact factor: 2.960
Authors: Steven C Martino; Marc N Elliott; Amelia M Haviland; Debra Saliba; Q Burkhart; David E Kanouse Journal: Health Serv Res Date: 2015-09-14 Impact factor: 3.402
Authors: Jennifer S Gewandter; William Dale; Allison Magnuson; Chintan Pandya; Charles E Heckler; Tatyana Lemelman; Breton Roussel; Rafa Ifthikhar; James Dolan; Katia Noyes; Supriya G Mohile Journal: J Geriatr Oncol Date: 2015-09-11 Impact factor: 3.599
Authors: M Elizabeth Wilcox; Elizabeth A Freiheit; Peter Faris; David B Hogan; Scott B Patten; Todd Anderson; William A Ghali; Merril Knudtson; Andrew Demchuk; Colleen J Maxwell Journal: BMC Psychiatry Date: 2016-08-04 Impact factor: 3.630
Authors: Jesse J Aarden; Marike van der Schaaf; Martin van der Esch; Lucienne A Reichardt; Rosanne van Seben; Jos A Bosch; Jos W R Twisk; Bianca M Buurman; Raoul H H Engelbert Journal: PLoS One Date: 2019-07-05 Impact factor: 3.240