OBJECTIVE: The objective of the study was to evaluate the performance of automatic quantitative ultrasound analysis (AQUA) texture extractor to predict fetal lung maturity tests in amniotic fluid. STUDY DESIGN: Singleton pregnancies (24.0-41.0 weeks) undergoing amniocentesis to assess fetal lung maturity (TDx fetal lung maturity assay [FLM]) were included. A manual-delineated box was placed in the lung area of a 4-chamber view of the fetal thorax. AQUA transformed the information into a set of descriptors. Genetic algorithms extracted the most relevant descriptors and then created and validated a model that could distinguish between mature or immature fetal lungs using TDx-FLM as a reference. RESULTS: Gestational age at enrollment was (mean [SD]) 32.2 (4.5) weeks. According to the TDx-FLM results, 41 samples were mature and 62 were not. The imaging biomarker based on AQUA presented a sensitivity 95.1%, specificity 85.7%, and an accuracy 90.3% to predict a mature or immature lung. CONCLUSION: Fetal lung ultrasound textures extracted by AQUA provided robust features to predict TDx-FLM results.
OBJECTIVE: The objective of the study was to evaluate the performance of automatic quantitative ultrasound analysis (AQUA) texture extractor to predict fetal lung maturity tests in amniotic fluid. STUDY DESIGN: Singleton pregnancies (24.0-41.0 weeks) undergoing amniocentesis to assess fetal lung maturity (TDx fetal lung maturity assay [FLM]) were included. A manual-delineated box was placed in the lung area of a 4-chamber view of the fetal thorax. AQUA transformed the information into a set of descriptors. Genetic algorithms extracted the most relevant descriptors and then created and validated a model that could distinguish between mature or immature fetal lungs using TDx-FLM as a reference. RESULTS: Gestational age at enrollment was (mean [SD]) 32.2 (4.5) weeks. According to the TDx-FLM results, 41 samples were mature and 62 were not. The imaging biomarker based on AQUA presented a sensitivity 95.1%, specificity 85.7%, and an accuracy 90.3% to predict a mature or immature lung. CONCLUSION: Fetal lung ultrasound textures extracted by AQUA provided robust features to predict TDx-FLM results.
Authors: Montse Palacio; Elisenda Bonet-Carne; Teresa Cobo; Alvaro Perez-Moreno; Joan Sabrià; Jute Richter; Marian Kacerovsky; Bo Jacobsson; Raúl A García-Posada; Fernando Bugatto; Ramon Santisteve; Àngels Vives; Mauro Parra-Cordero; Edgar Hernandez-Andrade; José Luis Bartha; Pilar Carretero-Lucena; Kai Lit Tan; Rogelio Cruz-Martínez; Minke Burke; Suseela Vavilala; Igor Iruretagoyena; Juan Luis Delgado; Mauro Schenone; Josep Vilanova; Francesc Botet; George S H Yeo; Jon Hyett; Jan Deprest; Roberto Romero; Eduard Gratacos Journal: Am J Obstet Gynecol Date: 2017-03-23 Impact factor: 8.661
Authors: Ana L Moreno-Espinosa; Ameth Hawkins-Villarreal; Xavier P Burgos-Artizzu; David Coronado-Gutierrez; Santiago Castelazo; Diana L Lip-Sosa; Javiera Fuenzalida; Dahiana M Gallo; Tatiana Peña-Ramirez; Paula Zuazagoitia; Miriam Muñoz; Mauro Parra-Cordero; Eduard Gratacòs; Montse Palacio Journal: Sci Rep Date: 2022-05-30 Impact factor: 4.996
Authors: Ana L Moreno-Espinosa; Ameth Hawkins-Villarreal; David Coronado-Gutierrez; Xavier P Burgos-Artizzu; Raigam J Martínez-Portilla; Tatiana Peña-Ramirez; Dahiana M Gallo; Stefan R Hansson; Eduard Gratacòs; Montse Palacio Journal: J Clin Med Date: 2022-08-20 Impact factor: 4.964