AIMS: NF-E2-related factor 2 (Nrf2) is involved in defence against oxidative stress in human cells. Nrf2 is over-expressed in many types of cancers suggesting that it plays a role in carcinogenesis and chemoresistance. We examined Nrf2 expression in osteosarcoma to determine its prognostic significance. METHODS: Nrf2 expression was assessed using immunohistochemistry in 58 specimens from patients with osteosarcoma. We investigated whether Nrf2 expression was associated with clinicopathological parameters. RESULTS: Nrf2 was positively expressed in 19 (32.8%) of 58 specimens. Nrf2 expression in osteosarcoma indicated a poor prognostic outcome (p = 0.0074), and correlated with worse disease-free survival (p = 0.0279). Nrf2 expression had a significant relationship with histological subtype (osteoblastic versus non-osteoblastic, p = 0.042); the non-osteoblastic subtype showed a higher rate of Nrf2 expression (50.0%) than the osteoblastic subtype (23.7%). Nrf2 expression showed no significant relationship with response to neoadjuvant chemotherapy (p = 0.115). Other clinicopathological parameters had no relationship with Nrf2 expression. CONCLUSION: Increased expression of Nrf2 is associated with a poor outcome and disease-free survival in osteosarcoma. Our results suggest that Nrf2 is a possible marker of poor prognosis in osteosarcoma.
AIMS: NF-E2-related factor 2 (Nrf2) is involved in defence against oxidative stress in human cells. Nrf2 is over-expressed in many types of cancers suggesting that it plays a role in carcinogenesis and chemoresistance. We examined Nrf2 expression in osteosarcoma to determine its prognostic significance. METHODS:Nrf2 expression was assessed using immunohistochemistry in 58 specimens from patients with osteosarcoma. We investigated whether Nrf2 expression was associated with clinicopathological parameters. RESULTS:Nrf2 was positively expressed in 19 (32.8%) of 58 specimens. Nrf2 expression in osteosarcoma indicated a poor prognostic outcome (p = 0.0074), and correlated with worse disease-free survival (p = 0.0279). Nrf2 expression had a significant relationship with histological subtype (osteoblastic versus non-osteoblastic, p = 0.042); the non-osteoblastic subtype showed a higher rate of Nrf2 expression (50.0%) than the osteoblastic subtype (23.7%). Nrf2 expression showed no significant relationship with response to neoadjuvant chemotherapy (p = 0.115). Other clinicopathological parameters had no relationship with Nrf2 expression. CONCLUSION: Increased expression of Nrf2 is associated with a poor outcome and disease-free survival in osteosarcoma. Our results suggest that Nrf2 is a possible marker of poor prognosis in osteosarcoma.
Authors: Patricia Coutinho de Souza; Nataliya Smith; Oluwatomisin Atolagbe; Jadith Ziegler; Charity Njoku; Megan Lerner; Marilyn Ehrenshaft; Ronald P Mason; Bill Meek; Scott M Plafker; Debra Saunders; Nadezda Mamedova; Rheal A Towner Journal: Free Radic Biol Med Date: 2015-06-26 Impact factor: 7.376
Authors: Y Liu; L Zhao; Y Ju; W Li; M Zhang; Y Jiao; J Zhang; S Wang; Y Wang; M Zhao; B Zhang; Y Zhao Journal: Cell Death Dis Date: 2014-08-07 Impact factor: 8.469