PURPOSE: To quantitatively evaluate interday, interreader, and intersite agreement of readers of hyperpolarized helium 3 (HPHe) MR images in patients with exercise-induced bronchoconstriction. MATERIALS AND METHODS: This HIPAA-compliant, institutional review board approved study included 13 patients with exercise-induced bronchoconstriction. On two separate days, HPHe MR imaging of the lungs was performed at baseline, immediately after a 10-minute exercise challenge (postchallenge), and 45 minutes after exercise (recovery). Patients were imaged at two sites, six at site A and seven at site B. Images were analyzed independently by multiple readers at each site. Lung volume, ventilation defect volume, ventilated volume, and the number of defects were measured quantitatively, and the location of defects was evaluated qualitatively at site A. Interday and interreader agreement were evaluated by using the intraclass correlation coefficient (ICC), and intersite agreement was evaluated by using a modified Bland-Altman analysis. RESULTS: The ICC between days for ventilation defect volume, ventilated volume, and number of defects was at least 0.74 at both sites. The ICC for lung volume was greater at site B (0.83-0.86) than at site A (0.60-0.65). Defects seen in the same location in the lung on both days included 19.7% of those seen on baseline images and 29.2% and 18.6% of defects on postchallenge and recovery images, respectively. Interreader ICC for each measurement was at least 0.82 for each site. Analysis of intersite agreement showed biases of 612 mL for lung volume, -60.7 mL for ventilation defect volume, 2.91% for ventilated volume, and -6.56 for number of defects. CONCLUSION: The reported measures of reproducibility of HPHe MR imaging may help in the design and interpretation of single- and multicenter studies of patients with exercise-induced bronchoconstriction.
PURPOSE: To quantitatively evaluate interday, interreader, and intersite agreement of readers of hyperpolarized helium 3 (HPHe) MR images in patients with exercise-induced bronchoconstriction. MATERIALS AND METHODS: This HIPAA-compliant, institutional review board approved study included 13 patients with exercise-induced bronchoconstriction. On two separate days, HPHe MR imaging of the lungs was performed at baseline, immediately after a 10-minute exercise challenge (postchallenge), and 45 minutes after exercise (recovery). Patients were imaged at two sites, six at site A and seven at site B. Images were analyzed independently by multiple readers at each site. Lung volume, ventilation defect volume, ventilated volume, and the number of defects were measured quantitatively, and the location of defects was evaluated qualitatively at site A. Interday and interreader agreement were evaluated by using the intraclass correlation coefficient (ICC), and intersite agreement was evaluated by using a modified Bland-Altman analysis. RESULTS: The ICC between days for ventilation defect volume, ventilated volume, and number of defects was at least 0.74 at both sites. The ICC for lung volume was greater at site B (0.83-0.86) than at site A (0.60-0.65). Defects seen in the same location in the lung on both days included 19.7% of those seen on baseline images and 29.2% and 18.6% of defects on postchallenge and recovery images, respectively. Interreader ICC for each measurement was at least 0.82 for each site. Analysis of intersite agreement showed biases of 612 mL for lung volume, -60.7 mL for ventilation defect volume, 2.91% for ventilated volume, and -6.56 for number of defects. CONCLUSION: The reported measures of reproducibility of HPHe MR imaging may help in the design and interpretation of single- and multicenter studies of patients with exercise-induced bronchoconstriction.
Authors: Harald E Möller; X Josette Chen; Brian Saam; Klaus D Hagspiel; G Allan Johnson; Talissa A Altes; Eduard E de Lange; Hans-Ulrich Kauczor Journal: Magn Reson Med Date: 2002-06 Impact factor: 4.668
Authors: Jim M Wild; Salma Ajraoui; Martin H Deppe; Steven R Parnell; Helen Marshall; Juan Parra-Robles; Rob H Ireland Journal: NMR Biomed Date: 2010-09-06 Impact factor: 4.044
Authors: Nicholas J Tustison; Brian B Avants; Lucia Flors; Talissa A Altes; Eduard E de Lange; John P Mugler; James C Gee Journal: J Magn Reson Imaging Date: 2011-08-11 Impact factor: 4.813
Authors: Neil Woodhouse; Jim M Wild; Martyn N J Paley; Stanislao Fichele; Zead Said; Andrew J Swift; Edwin J R van Beek Journal: J Magn Reson Imaging Date: 2005-04 Impact factor: 4.813
Authors: Nanae Tsuchiya; Mark L Schiebler; Michael D Evans; Robert V Cadman; Ronald L Sorkness; Robert F Lemanske; Daniel J Jackson; Nizar N Jarjour; Loren C Denlinger; Sean B Fain Journal: Pediatr Radiol Date: 2020-01-24
Authors: David G Mummy; Stanley J Kruger; Wei Zha; Ronald L Sorkness; Nizar N Jarjour; Mark L Schiebler; Loren C Denlinger; Michael D Evans; Sean B Fain Journal: J Allergy Clin Immunol Date: 2017-11-10 Impact factor: 10.793
Authors: Lukas Ebner; Jeff Kammerman; Bastiaan Driehuys; Mark L Schiebler; Robert V Cadman; Sean B Fain Journal: Eur J Radiol Date: 2016-09-16 Impact factor: 3.528
Authors: Stanley J Kruger; David J Niles; Bernard Dardzinski; Amy Harman; Nizar N Jarjour; Marcella Ruddy; Scott K Nagle; Christopher J Francois; Ronald L Sorkness; Ryan M Burton; Alejandro Munoz del Rio; Sean B Fain Journal: J Magn Reson Imaging Date: 2013-09-04 Impact factor: 4.813
Authors: Stanley J Kruger; Scott K Nagle; Marcus J Couch; Yoshiharu Ohno; Mitchell Albert; Sean B Fain Journal: J Magn Reson Imaging Date: 2015-07-27 Impact factor: 4.813
Authors: Chase S Hall; James D Quirk; Charles W Goss; Daphne Lew; Jim Kozlowski; Robert P Thomen; Jason C Woods; Nicholas J Tustison; John P Mugler; Lora Gallagher; Tammy Koch; Ken B Schechtman; Iulian C Ruset; F William Hersman; Mario Castro Journal: Am J Respir Crit Care Med Date: 2020-08-15 Impact factor: 21.405