Literature DB >> 23169440

The vagus nerve and the inflammatory reflex--linking immunity and metabolism.

Valentin A Pavlov1, Kevin J Tracey.   

Abstract

The vagus nerve has an important role in regulation of metabolic homeostasis, and efferent vagus nerve-mediated cholinergic signalling controls immune function and proinflammatory responses via the inflammatory reflex. Dysregulation of metabolism and immune function in obesity are associated with chronic inflammation, a critical step in the pathogenesis of insulin resistance and type 2 diabetes mellitus. Cholinergic mechanisms within the inflammatory reflex have, in the past 2 years, been implicated in attenuating obesity-related inflammation and metabolic complications. This knowledge has led to the exploration of novel therapeutic approaches in the treatment of obesity-related disorders.

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Year:  2012        PMID： 23169440      PMCID： PMC4082307          DOI： 10.1038/nrendo.2012.189

Source DB:  PubMed          Journal:  Nat Rev Endocrinol        ISSN： 1759-5029            Impact factor:   43.330


  141 in total

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  246 in total

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