| Literature DB >> 23168447 |
David L Perez1, Bradford C Dickerson, Scott M McGinnis, Daisy Sapolsky, Keith Johnson, Meghan Searl, Kirk R Daffner.
Abstract
Primary progressive aphasia (PPA) is a language predominant neurodegenerative disorder that has three recognized variants: nonfluent/agrammatic, semantic, and logopenic. This report describes a 60-year-old man who presented with a progressive decline in verbal output that does not fit the currently accepted PPA subtypes. The patient exhibited a paucity of verbal output and impaired phonemic fluency with minimal associated language, cognitive, or behavioral deficits. Focal cortical thinning/hypometabolism of the left superior frontal region and a cerebrospinal fluid profile not consistent with Alzheimer's disease pathology were identified. This case of isolated progressive dynamic aphasia extends the current boundaries of PPA diagnostic variants.Entities:
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Year: 2013 PMID: 23168447 PMCID: PMC3621037 DOI: 10.3233/JAD-121861
Source DB: PubMed Journal: J Alzheimers Dis ISSN: 1387-2877 Impact factor: 4.472