| Literature DB >> 23167609 |
Jeong Woo Lee1, Mee-Ree Han2, Jung-Hwan Park2.
Abstract
A microneedle system has been developed to deliver chemical and biological agents through the stratum corneum, which is the main barrier to drug delivery. Recently, microneedles have been fabricated from various kinds of polymers, including biocompatible polymer, biodegradable polymer, and water-soluble polymer. Polymer microneedles offer the benefits of ease of fabrication, cost-effectiveness, and mass production, as well as controlled drug release using the water solubility and degradation properties of polymer. In this review, the key features of polymer microneedles are discussed, including fabrication, materials, mechanical properties, drug delivery properties, and applications. Polymer microneedles provide a promising method for transdermal drug delivery by utilizing various physical and chemical properties of polymer.Entities:
Keywords: Microneedle; biodegradable; dissolving; microfabrication; polymer; transdermal drug delivery
Year: 2012 PMID： 23167609 DOI： 10.3109/1061186X.2012.741136
Source DB: PubMed Journal: J Drug Target ISSN： 1026-7158 Impact factor: 5.121