Literature DB >> 23167295

Total synthesis of natural p-quinol cochinchinenone.

Silvia Barradas1, Gloria Hernández-Torres, Antonio Urbano, M Carmen Carreño.   

Abstract

Cochinchinenone has been synthesized in only five steps and four pots and in 58% overall yield from commercially available 2,3-dimethoxy-4-hydroxy-benzaldehyde and OPMB-protected p-hydroxy acetophenone, the key step being the oxone-mediated oxidative dearomatization of the corresponding ketone-containing p-substituted phenol.

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Year:  2012        PMID: 23167295     DOI: 10.1021/ol302858r

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  4 in total

1.  The discovery of new phloroglucinol glycosides from Agrimonia pilosa and the mechanism of oxidative dearomatization of the methyl-substituted phloroglucinol derivatives.

Authors:  Jia Zhang; Ya-Nan Yang; Jian-Shuang Jiang; Zi-Ming Feng; Xiang Yuan; Xu Zhang; Pei-Cheng Zhang
Journal:  RSC Adv       Date:  2021-06-24       Impact factor: 3.361

2.  Efficient Oxidative Dearomatisations of Substituted Phenols Using Hypervalent Iodine (III) Reagents and Antiprotozoal Evaluation of the Resulting Cyclohexadienones against T. b. rhodesiense and P. falciparum Strain NF54.

Authors:  Nina Scheiber; Gregor Blaser; Eva-Maria Pferschy-Wenzig; Marcel Kaiser; Pascal Mäser; Armin Presser
Journal:  Molecules       Date:  2022-10-04       Impact factor: 4.927

3.  Vasculoprotective Effects of 3-Hydroxybenzaldehyde against VSMCs Proliferation and ECs Inflammation.

Authors:  Byung Soo Kong; Soo Jung Im; Yang Jong Lee; Yoon Hee Cho; Yu Ri Do; Jung Woo Byun; Cheol Ryong Ku; Eun Jig Lee
Journal:  PLoS One       Date:  2016-03-22       Impact factor: 3.240

4.  Concise Synthesis of Broussonone A.

Authors:  Hyeju Jo; Minho Choi; Mayavan Viji; Young Hee Lee; Young-Shin Kwak; Kiho Lee; Nam Song Choi; Yeon-Ju Lee; Heesoon Lee; Jin Tae Hong; Mi Kyeong Lee; Jae-Kyung Jung
Journal:  Molecules       Date:  2015-09-02       Impact factor: 4.411

  4 in total

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