Long-term treatment with high-dose of sildenafil in a thalassemic patient with pulmonary hypertension.

We report a case of a 37-years-old man, affected by thalassemia major, hypogonadotropic hypogonadism, chronic HCV-hepatitis, diabetes mellitus, severe osteoporosis, prior septic pulmonary embolism and pulmonary artery hypertension was performed a long-term treatment with high-dose of sildenafil (120 mg/die) with reduction of pulmonary arterial systolic pressure and of the dyspnea.