| Literature DB >> 23165895 |
Kogularamanan Suntharalingam1, Anna Łęczkowska, Mona A Furrer, Yilei Wu, Marina K Kuimova, Bruno Therrien, Andrew J P White, Ramon Vilar.
Abstract
Hits the spot: A cyclometalled platinum(II) complex with a substituted phenanthroline ligand is reported. The complex has high in vitro affinity for quadruplex DNA and upon binding its emission is switched on. The complex can be easily delivered to the cell by using a metallo-cage as a carrier (see illustration). By means of confocal microscopy, it is shown that the complex is released inside the cell, penetrates the nucleus and localises in the nucleoli.Entities:
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Year: 2012 PMID： 23165895 DOI： 10.1002/chem.201202990
Source DB: PubMed Journal: Chemistry ISSN： 0947-6539 Impact factor: 5.236