Wen-Chiuan Tsai1, Chih-Kung Lin, Ya-Sung Yang, De-Chuan Chan, Hong-Wei Gao, Fei-Ni Chang, Jong-Shiaw Jin. 1. Departments of *Pathology †Internal Medicine, National Defense Medical Center, Division of Infectious Diseases and Tropical Medicine ‡Surgery, National Defense Medical Center, Division of General Surgery, Tri-Service General Hospital, Taipei §Health Center of Don-Shan township of Yilan County, Yilan ∥Department of Pathology, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan, R.O.C.
Abstract
AIM: To test the association of LMX1A and osteopontin (OPN) expression with histologic differentiation or pathologic stage in pancreatic ductal adenocarcinoma. METHODS: Immunohistochemical analysis was performed to determine LMX1A and OPN expression in 100 surgical specimens obtained from Chinese patients with well-differentiated (n=15), moderately differentiated (n=65), and poorly differentiated (n=20) pancreatic ductal adenocarcinomas. RESULTS: LMX1A and OPN immunoreactivities were undetectable in normal pancreatic glandular epithelia. Stronger immunostaining for LMX1A and OPN was associated with advanced nuclear grades of pancreatic ductal adenocarcinomas (70.7 and 87.1 for grade I, 109.8 and 118.3 for grade II, and 171.3 and 183.8 for grade III), and advanced TNM and American Joint Committee on Cancer stages of pancreatic ductal adenocarcinomas. CONCLUSIONS: A higher expression of LMX1A and OPN is well correlated with histologic grade and pathologic stage of pancreatic ductal adenocarcinomas.
AIM: To test the association of LMX1A and osteopontin (OPN) expression with histologic differentiation or pathologic stage in pancreatic ductal adenocarcinoma. METHODS: Immunohistochemical analysis was performed to determine LMX1A and OPN expression in 100 surgical specimens obtained from Chinese patients with well-differentiated (n=15), moderately differentiated (n=65), and poorly differentiated (n=20) pancreatic ductal adenocarcinomas. RESULTS:LMX1A and OPN immunoreactivities were undetectable in normal pancreatic glandular epithelia. Stronger immunostaining for LMX1A and OPN was associated with advanced nuclear grades of pancreatic ductal adenocarcinomas (70.7 and 87.1 for grade I, 109.8 and 118.3 for grade II, and 171.3 and 183.8 for grade III), and advanced TNM and American Joint Committee on Cancer stages of pancreatic ductal adenocarcinomas. CONCLUSIONS: A higher expression of LMX1A and OPN is well correlated with histologic grade and pathologic stage of pancreatic ductal adenocarcinomas.
Authors: Sven H Loosen; Pia Hoening; Niklas Puethe; Mark Luedde; Martina Spehlmann; Tom F Ulmer; David V Cardenas; Sanchari Roy; Frank Tacke; Christian Trautwein; Ulf P Neumann; Tom Luedde; Christoph Roderburg Journal: Sci Rep Date: 2019-02-06 Impact factor: 4.379
Authors: Miller Huang; Jignesh Tailor; Qiqi Zhen; Aaron H Gillmor; Matthew L Miller; Holger Weishaupt; Justin Chen; Tina Zheng; Emily K Nash; Lauren K McHenry; Zhenyi An; Fubaiyang Ye; Yasuhiro Takashima; James Clarke; Harold Ayetey; Florence M G Cavalli; Betty Luu; Branden S Moriarity; Shirin Ilkhanizadeh; Lukas Chavez; Chunying Yu; Kathreena M Kurian; Thierry Magnaldo; Nicolas Sevenet; Philipp Koch; Steven M Pollard; Peter Dirks; Michael P Snyder; David A Largaespada; Yoon Jae Cho; Joanna J Phillips; Fredrik J Swartling; A Sorana Morrissy; Marcel Kool; Stefan M Pfister; Michael D Taylor; Austin Smith; William A Weiss Journal: Cell Stem Cell Date: 2019-06-13 Impact factor: 24.633