| Literature DB >> 23165089 |
Stuart Dowall1, Irene Taylor, Paul Yeates, Leonie Smith, Antony Rule, Linda Easterbrook, Christine Bruce, Nicola Cook, Kara Corbin-Lickfett, Cyril Empig, Kyle Schlunegger, Victoria Graham, Mike Dennis, Roger Hewson.
Abstract
Sequential sampling from animals challenged with highly pathogenic organisms, such as haemorrhagic fever viruses, is required for many pharmaceutical studies. Using the guinea pig model of Ebola virus infection, a catheterized system was used which had the benefits of allowing repeated sampling of the same cohort of animals, and also a reduction in the use of sharps at high biological containment. Levels of a PS-targeting antibody (Bavituximab) were measured in Ebola-infected animals and uninfected controls. Data showed that the pharmacokinetics were similar in both groups, therefore Ebola virus infection did not have an observable effect on the half-life of the antibody.Entities:
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Year: 2012 PMID： 23165089 DOI： 10.1016/j.antiviral.2012.11.003
Source DB: PubMed Journal: Antiviral Res ISSN： 0166-3542 Impact factor: 5.970