BACKGROUND: Heart failure (HF) accounts for >3 million hospital admissions annually in adults with acquired cardiovascular disease, but there are limited data on HF admissions in adults with congenital heart disease (ACHD). The purpose of this study was to test the hypotheses that HF admissions are common in ACHD and associated with significant morbidity and mortality. METHODS: The 2007 Nationwide Inpatient Sample was used to assess national prevalence, morbidities, and risk factors for mortality during hospitalizations among ACHD with HF. RESULTS: Of the 84,308 (95% CI 71,345-97,272) ACHD admissions in the United States in 2007, 17,193 (95% CI 14,157-20,229) had a diagnosis of HF (20%). ACHD with HF was associated with an increased risk of death compared to ACHD without HF (OR 3.3, 95% CI 2.6-4.1). On multivariable analysis independent risk factors for mortality included nonoperative intubation (OR 6.1, 95% CI 3.3-11.4), sepsis (OR 4.3, 95% CI 2.4-7.4), and acute myocardial infarction (OR 3.2, 95% CI 1.8-5.7). Cardiac defects associated with an increased risk of mortality included ventricular septal defects (VSDs) (OR 1.8, 95% CI 1.0-3.4). CONCLUSIONS: In this large population-based study, HF-related hospitalizations were common in ACHD and associated with an increased risk of death compared to non-HF admissions. The risk of mortality is increased with the diagnoses of VSDs and the presence of specific comorbidities such as respiratory failure and sepsis.
BACKGROUND:Heart failure (HF) accounts for >3 million hospital admissions annually in adults with acquired cardiovascular disease, but there are limited data on HF admissions in adults with congenital heart disease (ACHD). The purpose of this study was to test the hypotheses that HF admissions are common in ACHD and associated with significant morbidity and mortality. METHODS: The 2007 Nationwide Inpatient Sample was used to assess national prevalence, morbidities, and risk factors for mortality during hospitalizations among ACHD with HF. RESULTS: Of the 84,308 (95% CI 71,345-97,272) ACHD admissions in the United States in 2007, 17,193 (95% CI 14,157-20,229) had a diagnosis of HF (20%). ACHD with HF was associated with an increased risk of death compared to ACHD without HF (OR 3.3, 95% CI 2.6-4.1). On multivariable analysis independent risk factors for mortality included nonoperative intubation (OR 6.1, 95% CI 3.3-11.4), sepsis (OR 4.3, 95% CI 2.4-7.4), and acute myocardial infarction (OR 3.2, 95% CI 1.8-5.7). Cardiac defects associated with an increased risk of mortality included ventricular septal defects (VSDs) (OR 1.8, 95% CI 1.0-3.4). CONCLUSIONS: In this large population-based study, HF-related hospitalizations were common in ACHD and associated with an increased risk of death compared to non-HF admissions. The risk of mortality is increased with the diagnoses of VSDs and the presence of specific comorbidities such as respiratory failure and sepsis.
Authors: Michael D Seckeler; Ian D Thomas; Jennifer Andrews; Omar Meziab; Tabitha Moe; Elissa Heller; Scott E Klewer Journal: Pediatr Cardiol Date: 2017-11-15 Impact factor: 1.655
Authors: Ada C Stefanescu Schmidt; Doreen DeFaria Yeh; Sara Tabtabai; Kevin F Kennedy; Robert W Yeh; Ami B Bhatt Journal: Am J Cardiol Date: 2016-06-27 Impact factor: 2.778
Authors: Michelle Gurvitz; Kristin M Burns; Ralph Brindis; Craig S Broberg; Curt J Daniels; Stephanie M P N Fuller; Margaret A Honein; Paul Khairy; Karen S Kuehl; Michael J Landzberg; William T Mahle; Douglas L Mann; Ariane Marelli; Jane W Newburger; Gail D Pearson; Randall C Starling; Glenn R Tringali; Anne Marie Valente; Joseph C Wu; Robert M Califf Journal: J Am Coll Cardiol Date: 2016-04-26 Impact factor: 24.094
Authors: Priyanka Saha; Praneetha Potiny; Joseph Rigdon; Melissa Morello; Catherine Tcheandjieu; Anitra Romfh; Susan M Fernandes; Doff B McElhinney; Daniel Bernstein; George K Lui; Gary M Shaw; Erik Ingelsson; James R Priest Journal: Circulation Date: 2019-04-16 Impact factor: 29.690