Literature DB >> 23164043

Synthesis of vertex-differentiated icosahedral closo-boranes: polyfunctional scaffolds for targeted drug delivery.

Lalit N Goswami1, Zachary H Houston, Saurav J Sarma, Hairong Li, Satish S Jalisatgi, M Frederick Hawthorne.   

Abstract

We report methods for the synthesis of vertex-differentiated icosahedral closo-boranes. A single B-OH vertex of the icosahedral borane [closo-B(12)(OH)(12)](2-) was derivatized to prepare [closo-B(12)(OR)(OH)(11)](2-) using optimized alkylation conditions and purification procedures. Several representative vertex-differentiated icosahedral closo-boranes were prepared utilizing carbonate ester and azide-alkyne click chemistries on the surface of the closo-B(12)(2-) core.

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Year:  2012        PMID： 23164043      PMCID： PMC3528802          DOI： 10.1021/jo3021314

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  11 in total

1.  Applications of Radiolabeled Boron Clusters to the Diagnosis and Treatment of Cancer.

Authors:  M. Frederick Hawthorne; Andreas Maderna
Journal:  Chem Rev       Date:  1999-12-08       Impact factor: 60.622

2.  Twelvefold Functionalization of an Icosahedral Surface by Total Esterification of

Authors:  Andreas Maderna; Carolyn B. Knobler; M. Frederick Hawthorne
Journal:  Angew Chem Int Ed Engl       Date:  2001-05-04       Impact factor: 15.336

3.  Alkoxy derivatives of dodecaborate: discrete nanomolecular ions with tunable pseudometallic properties.

Authors:  Mark W Lee; Omar K Farha; M Frederick Hawthorne; Corwin H Hansch
Journal:  Angew Chem Int Ed Engl       Date:  2007       Impact factor: 15.336

4.  Synthesis of stable dodecaalkoxy derivatives of hypercloso-B12H12.

Authors:  Omar K Farha; Richard L Julius; Mark W Lee; Ramon E Huertas; Carolyn B Knobler; M Frederick Hawthorne
Journal:  J Am Chem Soc       Date:  2005-12-28       Impact factor: 15.419

5.  Extensions of the icosahedral closomer structure by using azide-alkyne click reactions.

Authors:  Lalit N Goswami; Shatadru Chakravarty; Mark W Lee; Satish S Jalisatgi; M Frederick Hawthorne
Journal:  Angew Chem Int Ed Engl       Date:  2011-04-08       Impact factor: 15.336

6.  A convenient route to diversely substituted icosahedral closomer nanoscaffolds.

Authors:  Satish S Jalisatgi; Vikas S Kulkarni; Betty Tang; Zachary H Houston; Mark W Lee; M Frederick Hawthorne
Journal:  J Am Chem Soc       Date:  2011-07-26       Impact factor: 15.419

7.  Organic syntheses on an icosahedral borane surface: closomer structures with twelvefold functionality.

Authors:  Tiejun Li; Satish S Jalisatgi; Michael J Bayer; Andreas Maderna; Saeed I Khan; M Frederick Hawthorne
Journal:  J Am Chem Soc       Date:  2005-12-21       Impact factor: 15.419

Review 8.  To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery.

Authors:  Fabienne Danhier; Olivier Feron; Véronique Préat
Journal:  J Control Release       Date:  2010-08-24       Impact factor: 9.776

9.  An improved method for the synthesis of [closo-B12(OH)12]-2.

Authors:  Michael J Bayer; M Frederick Hawthorne
Journal:  Inorg Chem       Date:  2004-03-22       Impact factor: 5.165

10.  A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Authors:  Y Matsumura; H Maeda
Journal:  Cancer Res       Date:  1986-12       Impact factor: 12.701
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  2 in total

1.  Rapid Synthesis of Redox-Active Dodecaborane B12(OR)12 Clusters Under Ambient Conditions.

Authors:  Alex I Wixtrom; Yanwu Shao; Dahee Jung; Charles W Machan; Shaunt N Kevork; Elaine A Qian; Jonathan C Axtell; Saeed I Khan; Clifford P Kubiak; Alexander M Spokoyny
Journal:  Inorg Chem Front       Date:  2016-03-03       Impact factor: 6.569

2.  cRGD peptide-conjugated icosahedral closo-B12(2-) core carrying multiple Gd3+-DOTA chelates for α(v)β3 integrin-targeted tumor imaging (MRI).

Authors:  Lalit N Goswami; Lixin Ma; Quanyu Cai; Saurav J Sarma; Satish S Jalisatgi; M Frederick Hawthorne
Journal:  Inorg Chem       Date:  2013-02-07       Impact factor: 5.165
  2 in total

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