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Literature DB >> 23162376

Colloidal stability of polymeric nanoparticles in biological fluids.

Stefano Lazzari¹, Davide Moscatelli, Fabio Codari, Mario Salmona, Massimo Morbidelli, Luisa Diomede.

Abstract

Estimating the colloidal stability of polymeric nanoparticles (NPs) in biological environments is critical for designing optimal preparations and to clarify the fate of these devices after administration. To characterize and quantify the physical stability of nanodevices suitable for biomedical applications, spherical NPs composed of poly-lactic acid (PLA) and poly-methyl-methacrylate (PMMA), in the range 100-200 nm, were prepared. Their stability in salt solutions, biological fluids, serum and tissue homogenates was analyzed by dynamic light scattering (DLS). The PMMA NPs remained stable in all fluids, while PLA NPs aggregated in gastric juice and spleen homogenate. The proposed stability test is therefore useful to see in advance whether NPs might aggregate when administered in vivo. To assess colloidal stability ex vivo as well, spectrophotofluorimetric analysis was employed, giving comparable results to DLS.

Entities: Chemical

Year: 2012 PMID： 23162376 PMCID： PMC3496558 DOI： 10.1007/s11051-012-0920-7

Source DB: PubMed Journal: J Nanopart Res ISSN： 1388-0764 Impact factor: 2.253

22 in total

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5. Size Dependent Uptake and Hemolytic Effect of Zinc Oxide Nanoparticles on Erythrocytes and Biomedical Potential of ZnO-Ferulic acid Conjugates.

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