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Literature DB >> 23161800

Nonenzymatic polymerization of ubiquitin: single-step synthesis and isolation of discrete ubiquitin oligomers.

Vivian H Trang¹, Ellen M Valkevich, Shoko Minami, Yi-Chen Chen, Ying Ge, Eric R Strieter.

Abstract

Linked: a method based on thiol-ene chemistry enables the synthesis and purification of ubiquitin oligomers with ≥4 units. This approach, which employs free-radical polymerization, can be applied towards the synthesis of homogeneous Lys6-linked ubiquitin oligomers currently inaccessible by enzymatic methods. By using these chains, one can study their roles in the ubiquitin proteasome system and the DNA damage response pathway.

Entities: CellLine Chemical Disease Gene Species

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Year: 2012 PMID： 23161800 PMCID： PMC4083817 DOI： 10.1002/anie.201207171

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

47 in total

1. Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease.

Authors: Eric B Dammer; Chan Hyun Na; Ping Xu; Nicholas T Seyfried; Duc M Duong; Dongmei Cheng; Marla Gearing; Howard Rees; James J Lah; Allan I Levey; John Rush; Junmin Peng
Journal: J Biol Chem Date: 2011-01-28 Impact factor: 5.157

Review 2. Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes.

Authors: Min Jae Lee; Byung-Hoon Lee; John Hanna; Randall W King; Daniel Finley
Journal: Mol Cell Proteomics Date: 2010-09-07 Impact factor: 5.911

3. Total chemical synthesis of a 304 amino acid K48-linked tetraubiquitin protein.

Authors: K S Ajish Kumar; Sudhir N Bavikar; Liat Spasser; Tal Moyal; Shimrit Ohayon; Ashraf Brik
Journal: Angew Chem Int Ed Engl Date: 2011-05-18 Impact factor: 15.336

Review 4. The spatial and temporal organization of ubiquitin networks.

Authors: Caroline Grabbe; Koraljka Husnjak; Ivan Dikic
Journal: Nat Rev Mol Cell Biol Date: 2011-03-30 Impact factor: 94.444

Review 5. BRCA1 and its toolbox for the maintenance of genome integrity.

Authors: Michael S Y Huen; Shirley M H Sy; Junjie Chen
Journal: Nat Rev Mol Cell Biol Date: 2009-12-23 Impact factor: 94.444

6. The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2.

Authors: Katherine E Wickliffe; Sonja Lorenz; David E Wemmer; John Kuriyan; Michael Rape
Journal: Cell Date: 2011-03-04 Impact factor: 41.582

7. Diverse polyubiquitin chains accumulate following 26S proteasomal dysfunction in mammalian neurones.

Authors: Lynn Bedford; Robert Layfield; R John Mayer; Junmin Peng; Ping Xu
Journal: Neurosci Lett Date: 2011-01-05 Impact factor: 3.046

8. Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin.

Authors: Monica C Rodrigo-Brenni; Scott A Foster; David O Morgan
Journal: Mol Cell Date: 2010-08-27 Impact factor: 17.970

9. The lysine 48 and lysine 63 ubiquitin conjugates are processed differently by the 26 s proteasome.

Authors: Andrew D Jacobson; Nan-Yan Zhang; Ping Xu; Ke-Jun Han; Seth Noone; Junmin Peng; Chang-Wei Liu
Journal: J Biol Chem Date: 2009-12-18 Impact factor: 5.157

10. Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate.

Authors: Anjanabha Saha; Steven Lewis; Gary Kleiger; Brian Kuhlman; Raymond J Deshaies
Journal: Mol Cell Date: 2011-04-08 Impact factor: 17.970

26 in total

1. Click chemistry for targeted protein ubiquitylation and ubiquitin chain formation.

Authors: Daniel Rösner; Tatjana Schneider; Daniel Schneider; Martin Scheffner; Andreas Marx
Journal: Nat Protoc Date: 2015-09-24 Impact factor: 13.491

2. Comparison of native and non-native ubiquitin oligomers reveals analogous structures and reactivities.

Authors: Grace H Pham; Ambar S J B Rana; E Nihal Korkmaz; Vivian H Trang; Qiang Cui; Eric R Strieter
Journal: Protein Sci Date: 2016-01-12 Impact factor: 6.725

3. Synthesis of a Bis-thio-acetone (BTA) Analogue of the Lysine Isopeptide Bond and its Application to Investigate the Effects of Ubiquitination and SUMOylation on α-Synuclein Aggregation and Toxicity.

Authors: Yuka E Lewis; Tharindumala Abeywardana; Yu Hsuan Lin; Ana Galesic; Matthew R Pratt
Journal: ACS Chem Biol Date: 2016-01-12 Impact factor: 5.100

Nonenzymatic polymerization of ubiquitin: single-step synthesis and isolation of discrete ubiquitin oligomers.

1. Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease.

Review 2. Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes.

3. Total chemical synthesis of a 304 amino acid K48-linked tetraubiquitin protein.

Review 4. The spatial and temporal organization of ubiquitin networks.

Review 5. BRCA1 and its toolbox for the maintenance of genome integrity.

6. The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2.

7. Diverse polyubiquitin chains accumulate following 26S proteasomal dysfunction in mammalian neurones.

8. Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin.

9. The lysine 48 and lysine 63 ubiquitin conjugates are processed differently by the 26 s proteasome.

10. Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate.

1. Click chemistry for targeted protein ubiquitylation and ubiquitin chain formation.

2. Comparison of native and non-native ubiquitin oligomers reveals analogous structures and reactivities.

3. Synthesis of a Bis-thio-acetone (BTA) Analogue of the Lysine Isopeptide Bond and its Application to Investigate the Effects of Ubiquitination and SUMOylation on α-Synuclein Aggregation and Toxicity.

4. Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity.

5. Reprogramming a Deubiquitinase into a Transamidase.

Review 6. Chemical biology approaches for studying posttranslational modifications.

Review 7. Peeling away the layers of ubiquitin signaling complexities with synthetic ubiquitin-protein conjugates.

8. Chemoenzymatic synthesis of bifunctional polyubiquitin substrates for monitoring ubiquitin chain remodeling.

9. Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation.

10. Subunit-Specific Labeling of Ubiquitin Chains by Using Sortase: Insights into the Selectivity of Deubiquitinases.