Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Pd-catalyzed C-H oxygenation with TFA/TFAA: expedient access to oxygen-containing heterocycles and late-stage drug modification.

Literature DB >> 23161485

Pd-catalyzed C-H oxygenation with TFA/TFAA: expedient access to oxygen-containing heterocycles and late-stage drug modification.

Gang Shan¹, Xinglin Yang, Linlin Ma, Yu Rao.

Abstract

Acid brings the oxygen: a general method for palladium-catalyzed C-H oxygenation has been developed for the facile synthesis of a wide range of functionalized phenols with readily available aryl ketones, benzoates, benzamides, acetanilides, and sulfonamides. A trifluoroacetic acid/trifluoroacetic acid anhydride solvent system serves as the oxygen source and is the critical factor for C-H activation.

Entities: Chemical

Mesh：

Substances：

Year: 2012 PMID： 23161485 DOI： 10.1002/anie.201207458

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

Keyword Cloud
Cited

19 in total

1. Palladium Catalyzed Aryl C-H Amination with O₂ via In Situ Formation of Peroxide-Based Oxidant(s) from Dioxane.

Authors: Adam B Weinstein; Shannon S Stahl
Journal: Catal Sci Technol Date: 2014-12-01 Impact factor: 6.119

2. Synthesis of 2-Acylphenol and Flavene Derivatives from the Ruthenium-Catalyzed Oxidative C-H Acylation of Phenols with Aldehydes.

Authors: Hanbin Lee; Chae S Yi
Journal: European J Org Chem Date: 2015-03

3. Total Synthesis of (-)-Kopsifoline A and (+)-Kopsifoline E.

Authors: In-Soo Myeong; Nadide Hazal Avci; Mohammad Movassaghi
Journal: Org Lett Date: 2021-11-12 Impact factor: 6.072

4. Pd(II)-catalyzed C-H functionalizations directed by distal weakly coordinating functional groups.

Authors: Gang Li; Li Wan; Guofu Zhang; Dasheng Leow; Jillian Spangler; Jin-Quan Yu
Journal: J Am Chem Soc Date: 2015-03-24 Impact factor: 15.419

5. Concise Total Syntheses of (+)-Haplocidine and (+)-Haplocine via Late-Stage Oxidation of (+)-Fendleridine Derivatives.

Authors: Kolby L White; Mohammad Movassaghi
Journal: J Am Chem Soc Date: 2016-08-26 Impact factor: 15.419

Pd-catalyzed C-H oxygenation with TFA/TFAA: expedient access to oxygen-containing heterocycles and late-stage drug modification.

1. Palladium Catalyzed Aryl C-H Amination with O₂ via In Situ Formation of Peroxide-Based Oxidant(s) from Dioxane.

2. Synthesis of 2-Acylphenol and Flavene Derivatives from the Ruthenium-Catalyzed Oxidative C-H Acylation of Phenols with Aldehydes.

3. Total Synthesis of (-)-Kopsifoline A and (+)-Kopsifoline E.

4. Pd(II)-catalyzed C-H functionalizations directed by distal weakly coordinating functional groups.

5. Concise Total Syntheses of (+)-Haplocidine and (+)-Haplocine via Late-Stage Oxidation of (+)-Fendleridine Derivatives.

6. Copper-catalyzed etherification of arene C-H bonds.

7. Rhoda-Electrocatalyzed Bimetallic C-H Oxygenation by Weak O-Coordination.

8. A bioinspired and biocompatible ortho-sulfiliminyl phenol synthesis.

Review 9. Transition-metal-catalyzed synthesis of phenols and aryl thiols.

10. Identification of monodentate oxazoline as a ligand for copper-promoted ortho-C-H hydroxylation and amination.