| Literature DB >> 23160791 |
Maohong Cao1, Heyi Zheng, Xiang Tan, Wei Xu, Ying Rui, Lei Li, Xiaofei Liu, Guangfei Xu, Gang Cui, Jian Xu, Jianhua Cao, Kaifu Ke, Qiyun Wu.
Abstract
CBLL1 (Casitas B-lineage lymphoma-transforming sequence-like protein 1) also known as Hakai, was originally identified as an E3 ubiquitin-ligase for the E-cadherin complex. Recent data have provided evidences for novel biological functional role of CBLL1 during tumor progression and other diseases. However, its distribution and function in the central nervous system (CNS) remains unclear. In this study, we found CBLL1 was significant up-regulation in cerebral cortex after LPS administration and immunofluorescent labeling indicated that CBLL1 was localized striking in the neurons. We also investigated co-staining of CBLL1 and active-caspase-3 and cyclin D1 in the cerebral cortex following LPS administration. Based on our data, we speculated that CBLL1 might play an important role in neuronal apoptosis following LPS administration and might provide a basis for the further study on its role in cell cycle re-entry in neuroinflammation in CNS.Entities:
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Year: 2012 PMID： 23160791 DOI： 10.1007/s10735-012-9467-2
Source DB: PubMed Journal: J Mol Histol ISSN： 1567-2379 Impact factor: 2.611