BACKGROUND: The interactions between kidney and thyroid functions have been known for many years; however, there are few studies on the extent of the improvements and long-term changes of renal function after thyroid hormone replacement therapy (THRT) in chronic kidney disease (CKD) patients. The purpose of this study was to determine how THRT affects the estimated glomerular filtration rate (eGFR) in CKD patients with primary hypothyroidism. METHODS: A retrospective investigation was performed on 51 Japanese patients (15 men and 36 women) with primary hypothyroidism. The changes in eGFR after THRT were examined according to the existence of CKD and severity of thyroid function. RESULTS: eGFR increased rapidly over the first 6 months after THRT in CKD patents, which was followed by a plateau. There was a correlation between eGFR and the severity of hypothyroidism, which was independent of age, and eGFR in severely hypothyroid patients significantly increased up to levels that were similar to mildly hypothyroid patients after THRT. eGFR improved more in the lower initial eGFR group and increased about 30 % in CKD patients (47.5 ± 7.7 vs. 62.1 ± 9.5 ml/min/1.73 m(2), P < 0.01). Moreover, eGFR in CKD patients with mild to moderate hypothyroidism was significantly increased compared to that in non-CKD patients. CONCLUSION: Our data suggested that hypothyroidism contributed to the reduction in eGFR, especially in CKD patients; therefore, patients with CKD should positively be examined for thyroid function, and appropriate THRT should be started if needed.
BACKGROUND: The interactions between kidney and thyroid functions have been known for many years; however, there are few studies on the extent of the improvements and long-term changes of renal function after thyroid hormone replacement therapy (THRT) in chronic kidney disease (CKD) patients. The purpose of this study was to determine how THRT affects the estimated glomerular filtration rate (eGFR) in CKDpatients with primary hypothyroidism. METHODS: A retrospective investigation was performed on 51 Japanese patients (15 men and 36 women) with primary hypothyroidism. The changes in eGFR after THRT were examined according to the existence of CKD and severity of thyroid function. RESULTS: eGFR increased rapidly over the first 6 months after THRT in CKD patents, which was followed by a plateau. There was a correlation between eGFR and the severity of hypothyroidism, which was independent of age, and eGFR in severely hypothyroidpatients significantly increased up to levels that were similar to mildly hypothyroidpatients after THRT. eGFR improved more in the lower initial eGFR group and increased about 30 % in CKDpatients (47.5 ± 7.7 vs. 62.1 ± 9.5 ml/min/1.73 m(2), P < 0.01). Moreover, eGFR in CKDpatients with mild to moderate hypothyroidism was significantly increased compared to that in non-CKDpatients. CONCLUSION: Our data suggested that hypothyroidism contributed to the reduction in eGFR, especially in CKDpatients; therefore, patients with CKD should positively be examined for thyroid function, and appropriate THRT should be started if needed.
Authors: Timothy Daniel Kayes; Gary A Weisman; Jean M Camden; Lucas T Woods; Cole Bredehoeft; Edward F Downey; James Cole; Helen Braley-Mullen Journal: J Immunol Date: 2016-08-12 Impact factor: 5.422
Authors: Connie M Rhee; Gregory A Brent; Csaba P Kovesdy; Offie P Soldin; Danh Nguyen; Matthew J Budoff; Steven M Brunelli; Kamyar Kalantar-Zadeh Journal: Nephrol Dial Transplant Date: 2014-02-25 Impact factor: 5.992
Authors: Baris Afsar; Mahmut Ilker Yilmaz; Dimitrie Siriopol; Hilmi Umut Unal; Mutlu Saglam; Murat Karaman; Mustafa Gezer; Alper Sonmez; Tayfun Eyileten; Ibrahim Aydin; Salih Hamcan; Yusuf Oguz; Adrian Covic; Mehmet Kanbay Journal: J Nephrol Date: 2016-04-02 Impact factor: 3.902