Robert Krysiak1, Boguslaw Okopien. 1. Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medykow 18, Katowice, Poland. r.krysiak@interia.pl
Abstract
BACKGROUND: No previous study investigated statin action on monocyte cytokine release and systemic inflammation in patients with isolated hypertriglyceridemia. METHODS: Our study included 43 subjects with isolated hypertriglyceridemia and peripheral artery stenosis randomly allocated to one of two groups, treated for 12 weeks with either simvastatin (40 mg twice daily) or placebo. Plasma lipids, glucose homeostasis markers, plasma C-reactive protein and monocyte cytokine release were determined on the day of allocation and at the end of the treatment period. RESULTS:Simvastatin, but not placebo, reduced monocyte release of tumor necrosis factor-α, interleukin-6, interleukin-1β and monocyte chemoattractant protein-1, as well decreased plasma levels of C-reactive protein. CONCLUSIONS: Our study shows that simvastatin reduces monocyte secretory function and has systemic anti-inflammatory properties in patients with isolated hypertriglyceridemia.
RCT Entities:
BACKGROUND: No previous study investigated statin action on monocyte cytokine release and systemic inflammation in patients with isolated hypertriglyceridemia. METHODS: Our study included 43 subjects with isolated hypertriglyceridemia and peripheral artery stenosis randomly allocated to one of two groups, treated for 12 weeks with either simvastatin (40 mg twice daily) or placebo. Plasma lipids, glucose homeostasis markers, plasma C-reactive protein and monocyte cytokine release were determined on the day of allocation and at the end of the treatment period. RESULTS:Simvastatin, but not placebo, reduced monocyte release of tumor necrosis factor-α, interleukin-6, interleukin-1β and monocyte chemoattractant protein-1, as well decreased plasma levels of C-reactive protein. CONCLUSIONS: Our study shows that simvastatin reduces monocyte secretory function and has systemic anti-inflammatory properties in patients with isolated hypertriglyceridemia.
Authors: Nicholas Don-Doncow; Lotte Vanherle; Frank Matthes; Sine Kragh Petersen; Hana Matuskova; Sara Rattik; Anetta Härtlova; Anja Meissner Journal: NPJ Aging Mech Dis Date: 2021-08-04