BACKGROUND & AIMS: Colorectal cancer (CRC) is the second-most common cancer in Hong Kong. Relatives of patients with CRC have an increased risk of colorectal neoplasm. We assessed the prevalence of advanced neoplasms among asymptomatic siblings of patients with CRC. METHODS: Patients with CRC were identified from the Prince of Wales Hospital CRC Surgery Registry from 2001 to 2011. Colonoscopies were performed for 374 siblings of patients (age, 52.6 ± 7.4 y) and 374 age- and sex-matched siblings of healthy subjects who had normal colonoscopies and did not have a family history of CRC (controls, 52.7 ± 7.4 y). We identified individuals with advanced neoplasms (defined as cancers or adenomas of at least 10 mm in diameter, high-grade dysplasia, with villous or tubulovillous characteristics). RESULTS: The prevalence of advanced neoplasms was 7.5% among siblings of patients and 2.9% among controls (matched odds ratio [mOR], 3.07; 95% confidence interval [CI], 1.5-6.3; P = .002). The prevalence of adenomas larger than 10 mm was higher among siblings of patients than in controls (5.9% vs 2.1%; mOR, 3.34; 95% CI, 1.45-7.66; P = .004), as was the presence of colorectal adenomas (31.0% vs 18.2%; mOR, 2.19; 95% CI, 1.52-3.17; P < .001). Six cancers were detected among siblings of patients; no cancers were detected in controls. The prevalence of advanced neoplasms among siblings of patients was higher when their index case was female (mOR, 4.95; 95% CI, 1.81-13.55) and had distally located CRC (mOR, 3.10; 95% CI, 1.34-7.14). CONCLUSIONS: In Hong Kong, siblings of patients with CRC have a higher prevalence of advanced neoplasms, including CRC, than siblings of healthy individuals. Screening is indicated in this high-risk population. ClinicalTrials.gov number: NCT00164944.
BACKGROUND & AIMS:Colorectal cancer (CRC) is the second-most common cancer in Hong Kong. Relatives of patients with CRC have an increased risk of colorectal neoplasm. We assessed the prevalence of advanced neoplasms among asymptomatic siblings of patients with CRC. METHODS:Patients with CRC were identified from the Prince of Wales Hospital CRC Surgery Registry from 2001 to 2011. Colonoscopies were performed for 374 siblings of patients (age, 52.6 ± 7.4 y) and 374 age- and sex-matched siblings of healthy subjects who had normal colonoscopies and did not have a family history of CRC (controls, 52.7 ± 7.4 y). We identified individuals with advanced neoplasms (defined as cancersoradenomas of at least 10 mm in diameter, high-grade dysplasia, with villous or tubulovillous characteristics). RESULTS: The prevalence of advanced neoplasms was 7.5% among siblings of patients and 2.9% among controls (matched odds ratio [mOR], 3.07; 95% confidence interval [CI], 1.5-6.3; P = .002). The prevalence of adenomas larger than 10 mm was higher among siblings of patients than in controls (5.9% vs 2.1%; mOR, 3.34; 95% CI, 1.45-7.66; P = .004), as was the presence of colorectal adenomas (31.0% vs 18.2%; mOR, 2.19; 95% CI, 1.52-3.17; P < .001). Six cancers were detected among siblings of patients; no cancers were detected in controls. The prevalence of advanced neoplasms among siblings of patients was higher when their index case was female (mOR, 4.95; 95% CI, 1.81-13.55) and had distally located CRC (mOR, 3.10; 95% CI, 1.34-7.14). CONCLUSIONS: In Hong Kong, siblings of patients with CRC have a higher prevalence of advanced neoplasms, including CRC, than siblings of healthy individuals. Screening is indicated in this high-risk population. ClinicalTrials.gov number: NCT00164944.
Authors: Qinyan Gao; Kelvin K F Tsoi; Hoyee W Hirai; Martin C S Wong; Francis K L Chan; Justin C Y Wu; James Y W Lau; Joseph J Y Sung; Siew C Ng Journal: Am J Gastroenterol Date: 2015-03-10 Impact factor: 10.864
Authors: Elizabeth T Jacobs; Samir Gupta; John A Baron; Amanda J Cross; David A Lieberman; Gwen Murphy; María Elena Martínez Journal: Am J Gastroenterol Date: 2018-02-20 Impact factor: 10.864
Authors: Perry J Pickhardt; Ifeanyi Mbah; B Dustin Pooler; Oliver T Chen; J Louis Hinshaw; Jennifer M Weiss; David H Kim Journal: AJR Am J Roentgenol Date: 2017-01-26 Impact factor: 3.959
Authors: Martin C S Wong; Jessica Y L Ching; Han-Mo Chiu; Kai Chun Wu; Rungsun Rerknimitr; Jingnan Li; Deng-Chiang Wu; Khean Lee Goh; Takahisa Matsuda; Hyun-Soo Kim; Rupert Leong; Khay Guan Yeoh; Vui Heng Chong; Jose D Sollano; Furqaan Ahmed; Jayaram Menon; Siew C Ng; Justin C Y Wu; Francis K L Chan; Joseph J Y Sung Journal: Am J Gastroenterol Date: 2016-03-15 Impact factor: 10.864
Authors: Cesare Hassan; B Dustin Pooler; David H Kim; Antonio Rinaldi; Alessandro Repici; Perry J Pickhardt Journal: Cancer Date: 2013-06-10 Impact factor: 6.860