Emerging concepts in the management and treatment of osteonecrosis of the jaw.

Since the first description of bone necrosis in patients receiving bisphosphonate therapy in 2004, there have been multiple retrospective, prospective, and case-control studies that have served to characterize the diagnosis, associated risk factors, and treatment of this new complication. Bisphosphonate-related osteonecrosis of the jaw is at present associated with several risk factors that are identified across several disciplines in medicine and dentistry. With this level of broad-based recognition, new clinical and basic science research initiatives have begun and are likely to elucidate the etiopathogenesis of this disease process, significantly improving the level of disease management and prevention.