Literature DB >> 23159041

Contribution to investigation of antimicrobial activity of styrylquinolines.

Wioleta Cieslik1, Robert Musiol, Jacek E Nycz, Josef Jampilek, Marcela Vejsova, Mariusz Wolff, Barbara Machura, Jaroslaw Polanski.   

Abstract

Series of new ring-substituted styrylquinolines and two oxorhenium complexes were prepared and characterized. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed against fungal and bacterial strains. Some compounds were active against bacteria at micromolar level and against fungi at submicromolar level. Compounds 5,7-dichloro-2-[2-(2-ethoxyphenyl)vinyl]quinolin-8-ol expressed excellent antifungal activity comparable with or higher than the standard fluconazole as well as antibacterial activity against Staphylococcus strains comparable with or higher than the standards bacitracin, penicillin and ciprofloxacin. The structure-activity relationships are discussed.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 23159041     DOI： 10.1016/j.bmc.2012.10.027

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  12 in total

1.  Synthesis of New Styrylquinoline Cellular Dyes, Fluorescent Properties, Cellular Localization and Cytotoxic Behavior.

Authors:  Marzena Rams-Baron; Mateusz Dulski; Anna Mrozek-Wilczkiewicz; Mateusz Korzec; Wioleta Cieslik; Ewelina Spaczyńska; Piotr Bartczak; Alicja Ratuszna; Jaroslaw Polanski; Robert Musiol
Journal:  PLoS One       Date:  2015-06-26       Impact factor: 3.240

2.  The Eighth Central European Conference "Chemistry towards Biology": Snapshot.

Authors:  András Perczel; Atanas G Atanasov; Vladimír Sklenář; Jiří Nováček; Veronika Papoušková; Pavel Kadeřávek; Lukáš Žídek; Henryk Kozłowski; Joanna Wątły; Aleksandra Hecel; Paulina Kołkowska; Jaroslav Koča; Radka Svobodová-Vařeková; Lukáš Pravda; David Sehnal; Vladimír Horský; Stanislav Geidl; Ricardo D Enriz; Pavel Matějka; Adéla Jeništová; Marcela Dendisová; Alžběta Kokaislová; Volkmar Weissig; Mark Olsen; Aidan Coffey; Jude Ajuebor; Ruth Keary; Marta Sanz-Gaitero; Mark J van Raaij; Olivia McAuliffe; Birgit Waltenberger; Andrei Mocan; Karel Šmejkal; Elke H Heiss; Marc Diederich; Robert Musioł; Janez Košmrlj; Jarosław Polański; Josef Jampílek
Journal:  Molecules       Date:  2016-10-17       Impact factor: 4.411

3.  Theoretical and Experimental Investigations of Large Stokes Shift Fluorophores Based on a Quinoline Scaffold.

Authors:  Barbara Czaplińska; Katarzyna Malarz; Anna Mrozek-Wilczkiewicz; Aneta Slodek; Mateusz Korzec; Robert Musiol
Journal:  Molecules       Date:  2020-05-27       Impact factor: 4.411

4.  The Forty-Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot †.

Authors:  Pavel Mucaji; Atanas G Atanasov; Andrzej Bak; Violetta Kozik; Karolina Sieron; Mark Olsen; Weidong Pan; Yazhou Liu; Shengchao Hu; Junjie Lan; Norbert Haider; Robert Musiol; Jan Vanco; Marc Diederich; Seungwon Ji; Jan Zitko; Dongdong Wang; Danica Agbaba; Katarina Nikolic; Slavica Oljacic; Jelica Vucicevic; Daniela Jezova; Anna Tsantili-Kakoulidou; Fotios Tsopelas; Constantinos Giaginis; Teresa Kowalska; Mieczyslaw Sajewicz; Jerzy Silberring; Przemyslaw Mielczarek; Marek Smoluch; Izabela Jendrzejewska; Jaroslaw Polanski; Josef Jampilek
Journal:  Molecules       Date:  2017-10-28       Impact factor: 4.411

5.  8-Hydroxyquinolines are bactericidal against Mycobacterium tuberculosis.

Authors:  Joshua O Odingo; Julie V Early; Jake Smith; James Johnson; Mai A Bailey; Megan Files; Junitta Guzman; Juliane Ollinger; Aaron Korkegian; Anuradha Kumar; Yulia Ovechkina; Tanya Parish
Journal:  Drug Dev Res       Date:  2019-03-20       Impact factor: 4.360

6.  First synthesis of novel 2,4-bis((E)-styryl)quinoline-3-carboxylate derivatives and their antitumor activity.

Authors:  Wentao Gao; Zhiyuan Li; Qiqi Xu; Yang Li
Journal:  RSC Adv       Date:  2018-11-19       Impact factor: 4.036

Review 7.  Recent synthetic efforts in the preparation of 2-(3,4)-alkenyl (aryl) quinoline molecules towards anti-kinetoplastid agents.

Authors:  Dayana Orozco; Vladimir V Kouznetsov; Armando Bermúdez; Leonor Y Vargas Méndez; Arturo René Mendoza Salgado; Carlos Mario Meléndez Gómez
Journal:  RSC Adv       Date:  2020-01-29       Impact factor: 4.036

8.  Design, Synthesis and In Vitro Activity of Anticancer Styrylquinolines. The p53 Independent Mechanism of Action.

Authors:  Anna Mrozek-Wilczkiewicz; Ewelina Spaczynska; Katarzyna Malarz; Wioleta Cieslik; Marzena Rams-Baron; Vladimír Kryštof; Robert Musiol
Journal:  PLoS One       Date:  2015-11-23       Impact factor: 3.240

9.  Antifungal Styryloquinolines as Candida albicans Efflux Pump Inhibitors: Styryloquinolines are ABC Transporter Inhibitors.

Authors:  Wioleta Cieslik; Joanna Szczepaniak; Anna Krasowska; Robert Musiol
Journal:  Molecules       Date:  2020-01-15       Impact factor: 4.411

Review 10.  A review on quinoline derivatives as anti-methicillin resistant Staphylococcus aureus (MRSA) agents.

Authors:  Pradeep Kumar
Journal:  BMC Chem       Date:  2020-03-13
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