Literature DB >> 23157258

Mitochondria-targeted plastoquinone antioxidant SkQR1 decreases trauma-induced neurological deficit in rat.

N K Isaev1, S V Novikova, E V Stelmashook, I V Barskov, D N Silachev, L G Khaspekov, V P Skulachev, D B Zorov.   

Abstract

A protective effect of a mitochondria-targeted antioxidant, a cationic rhodamine derivative linked to a plastoquinone molecule (10-(6'-plastoquinonyl)decylrhodamine-19, SkQR1) was studied in the model of open focal trauma of rat brain sensorimotor cortex. It was found that daily intraperitoneal injections of SkQR1 (100 nmol/kg) for 4 days after the trauma improved performance in a test characterizing neurological deficit and decreased the volume of the damaged cortical area. Our results suggest that SkQR1 exhibits profound neuroprotective effect, which may be explained by its antioxidative activity.

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Year:  2012        PMID： 23157258     DOI： 10.1134/S0006297912090052

Source DB:  PubMed          Journal:  Biochemistry (Mosc)        ISSN： 0006-2979            Impact factor:   2.487


  14 in total

1.  Effect of Silk Fibroin on Neuroregeneration After Traumatic Brain Injury.

Authors:  M M Moisenovich; E Y Plotnikov; A M Moysenovich; D N Silachev; T I Danilina; E S Savchenko; M M Bobrova; L A Safonova; V V Tatarskiy; M S Kotliarova; I I Agapov; D B Zorov
Journal:  Neurochem Res       Date:  2018-12-05       Impact factor: 3.996

Review 2.  Evolution of cytochrome bc complexes: from membrane-anchored dehydrogenases of ancient bacteria to triggers of apoptosis in vertebrates.

Authors:  Daria V Dibrova; Dmitry A Cherepanov; Michael Y Galperin; Vladimir P Skulachev; Armen Y Mulkidjanian
Journal:  Biochim Biophys Acta       Date:  2013-07-19

3.  The mitochondria-targeted antioxidants and remote kidney preconditioning ameliorate brain damage through kidney-to-brain cross-talk.

Authors:  Denis N Silachev; Nikolay K Isaev; Irina B Pevzner; Ljubava D Zorova; Elena V Stelmashook; Svetlana V Novikova; Egor Y Plotnikov; Vladimir P Skulachev; Dmitry B Zorov
Journal:  PLoS One       Date:  2012-12-14       Impact factor: 3.240

4.  Neuroprotective Effects of Mitochondria-Targeted Plastoquinone in a Rat Model of Neonatal Hypoxic⁻Ischemic Brain Injury.

Authors:  Denis N Silachev; Egor Y Plotnikov; Irina B Pevzner; Ljubava D Zorova; Anastasia V Balakireva; Mikhail V Gulyaev; Yury A Pirogov; Vladimir P Skulachev; Dmitry B Zorov
Journal:  Molecules       Date:  2018-07-27       Impact factor: 4.411

5.  Mitochondria-Targeted Antioxidants as Potential Therapy for the Treatment of Traumatic Brain Injury.

Authors:  Elena V Stelmashook; Nickolay K Isaev; Elisaveta E Genrikhs; Svetlana V Novikova
Journal:  Antioxidants (Basel)       Date:  2019-05-08

6.  Pros and Cons of Use of Mitochondria-Targeted Antioxidants.

Authors:  Egor Y Plotnikov; Dmitry B Zorov
Journal:  Antioxidants (Basel)       Date:  2019-08-17

Review 7.  A Review of Plant Extracts and Plant-Derived Natural Compounds in the Prevention/Treatment of Neonatal Hypoxic-Ischemic Brain Injury.

Authors:  Hadi Mohsenpour; Mirko Pesce; Antonia Patruno; Azam Bahrami; Pardis Mohammadi Pour; Mohammad Hosein Farzaei
Journal:  Int J Mol Sci       Date:  2021-01-15       Impact factor: 5.923

Review 8.  Mitochondria-Targeted Antioxidants: A Step towards Disease Treatment.

Authors:  Qian Jiang; Jie Yin; Jiashun Chen; Xiaokang Ma; Miaomiao Wu; Gang Liu; Kang Yao; Bie Tan; Yulong Yin
Journal:  Oxid Med Cell Longev       Date:  2020-12-03       Impact factor: 6.543

9.  Age-Related Changes in Bone-Marrow Mesenchymal Stem Cells.

Authors:  Valentina A Babenko; Denis N Silachev; Tatyana I Danilina; Kirill V Goryunov; Irina B Pevzner; Ljubava D Zorova; Vasily A Popkov; Valery P Chernikov; Egor Y Plotnikov; Gennady T Sukhikh; Dmitry B Zorov
Journal:  Cells       Date:  2021-05-21       Impact factor: 6.600

10.  The Delayed Neuroprotective Effect of Methylene Blue in Experimental Rat Brain Trauma.

Authors:  Elizaveta E Genrikhs; Elena V Stelmashook; Dmitriy N Voronkov; Svetlana V Novikova; Olga P Alexandrova; Mikhail V Gulyaev; Nickolay K Isaev
Journal:  Antioxidants (Basel)       Date:  2020-05-02
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