Literature DB >> 2315700

Requirement for activin A and transforming growth factor--beta 1 pro-regions in homodimer assembly.

A M Gray1, A J Mason.   

Abstract

Many proteins are initially synthesized as part of a large precursor. The role of the pro-region in the biosynthesis of transforming growth factor--beta 1 (TGF-beta 1) and activin A, two structurally related disulfide-linked homodimers synthesized as large precursors, was studied. Vectors that expressed either the pro-region or the mature regions of these molecules were used in complementation experiments, only when the pro-region was coexpressed with the mature region did intracellular dimerization and secretion of biologically active homodimers occur. The pro-regions of activin A and TGF-beta 1, therefore, aid the folding, disulfide bond formation, and export of their respective homodimers.

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Year:  1990        PMID： 2315700     DOI： 10.1126/science.2315700

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  73 in total

1.  The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-beta superfamily member, acts as a quality control determinant for correctly folded MIC-1.

Authors:  A R Bauskin; H P Zhang; W D Fairlie; X Y He; P K Russell; A G Moore; D A Brown; K K Stanley; S N Breit
Journal:  EMBO J       Date:  2000-05-15       Impact factor: 11.598

2.  Novel mechanisms control the folding and assembly of lambda5/14.1 and VpreB to produce an intact surrogate light chain.

Authors:  Y Minegishi; L M Hendershot; M E Conley
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-16       Impact factor: 11.205

3.  The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor.

Authors:  Y Cui; R Hackenmiller; L Berg; F Jean; T Nakayama; G Thomas; J L Christian
Journal:  Genes Dev       Date:  2001-11-01       Impact factor: 11.361

4.  The Toxoplasma gondii protein MIC3 requires pro-peptide cleavage and dimerization to function as adhesin.

Authors:  Odile Cérède; Jean François Dubremetz; Daniel Bout; Maryse Lebrun
Journal:  EMBO J       Date:  2002-06-03       Impact factor: 11.598

5.  Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta.

Authors:  J Saharinen; J Keski-Oja
Journal:  Mol Biol Cell       Date:  2000-08       Impact factor: 4.138

6.  Molecular cloning of a human gene that is a member of the nerve growth factor family.

Authors:  K R Jones; L F Reichardt
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

7.  Activin A binds to perlecan through its pro-region that has heparin/heparan sulfate binding activity.

Authors:  Shaoliang Li; Chisei Shimono; Naoko Norioka; Itsuko Nakano; Tetsuo Okubo; Yoshiko Yagi; Maria Hayashi; Yuya Sato; Hitomi Fujisaki; Shunji Hattori; Nobuo Sugiura; Koji Kimata; Kiyotoshi Sekiguchi
Journal:  J Biol Chem       Date:  2010-09-15       Impact factor: 5.157

8.  Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo.

Authors:  Osamu Shimmi; David Umulis; Hans Othmer; Michael B O'Connor
Journal:  Cell       Date:  2005-03-25       Impact factor: 41.582

Review 9.  Structural Biology and Evolution of the TGF-β Family.

Authors:  Andrew P Hinck; Thomas D Mueller; Timothy A Springer
Journal:  Cold Spring Harb Perspect Biol       Date:  2016-12-01       Impact factor: 10.005

10.  Dominant negative mutants of transforming growth factor-beta 1 inhibit the secretion of different transforming growth factor-beta isoforms.

Authors:  A R Lopez; J Cook; P L Deininger; R Derynck
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272
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