| Literature DB >> 23154840 |
Antoine M Saab1, Alessandra Guerrini, Gianni Sacchetti, Silvia Maietti, Maʼen Zeino, Joachim Arend, Roberto Gambari, Francesco Bernardi, Thomas Efferth.
Abstract
Juniperus excelsa fruit essential oil as well as J. oxycedrus, Cedrus libani, and Pinus pinea wood essential oils have been obtained with yields between 2.2 ± 0.3 % to 3.4 ± 0.5 % and analyzed by gas chromatography. Sesquiterpenes mainly characterized C. libani and J. oxycedrus essential oils, while in P. pinea and J. excelsa, monoterpenes were the most abundant compounds. In J. oxycedrus, cis-calamenene (7.8 %), cuparene (3.8 %), and cis-thujopsenal (2.0 %) have been detected for the first time. The cytotoxic activity of these essential oils against drug-sensitive CCRF-CEM and multidrug-resistant P-glycoprotein-expressing CEM/ADR5000 leukemia cells has been investigated (IC₅₀ values: 29.46 to 61.54 µg/mL). Remarkably, multidrug-resistant CEM/ADR5000 cells did not reveal cross-resistance, indicating that these essential oils might be useful to treat otherwise drug-resistant and refractory tumors. Georg Thieme Verlag KG Stuttgart · New York.Entities:
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Year: 2012 PMID： 23154840 DOI： 10.1055/s-0032-1327896
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352