OBJECTIVE: To investigate the influence of glycemic variability on the HbA1c level in elderly male patients with type 2 diabetes (T2DM). METHODS: The 24-h glucose profiles were obtained using a continuous glucose monitoring system in 291 elderly male type 2 diabetic patients. The relationship between the glycemic variability and HbA1c level was assessed in these patients. RESULTS: The mean amplitude of glycemic excursions (MAGE) in patients with HbA1c ≥7.0% was significantly higher than in patients with HbA1c <7.0% (4.33±1.67 vs. 3.48±1.46 mmol/L, p<0.001). A simple (Pearson's) correlation analysis indicated that the MAGE was significantly correlated with the HbA1c (r=0.229, p<0.001). Compared with the lowest quartile, the highest quartile of the MAGE was associated with a significantly increased risk of having a HbA1c ≥7.0% after multiple adjustments (p (for trend) <0.001). CONCLUSION: The glycemic variability had a significant influence on the HbA1c level in elderly male patients with T2DM. The present data suggests that patients with higher glycemic variability might have higher HbA1c levels.
OBJECTIVE: To investigate the influence of glycemic variability on the HbA1c level in elderly male patients with type 2 diabetes (T2DM). METHODS: The 24-h glucose profiles were obtained using a continuous glucose monitoring system in 291 elderly male type 2 diabeticpatients. The relationship between the glycemic variability and HbA1c level was assessed in these patients. RESULTS: The mean amplitude of glycemic excursions (MAGE) in patients with HbA1c ≥7.0% was significantly higher than in patients with HbA1c <7.0% (4.33±1.67 vs. 3.48±1.46 mmol/L, p<0.001). A simple (Pearson's) correlation analysis indicated that the MAGE was significantly correlated with the HbA1c (r=0.229, p<0.001). Compared with the lowest quartile, the highest quartile of the MAGE was associated with a significantly increased risk of having a HbA1c ≥7.0% after multiple adjustments (p (for trend) <0.001). CONCLUSION: The glycemic variability had a significant influence on the HbA1c level in elderly male patients with T2DM. The present data suggests that patients with higher glycemic variability might have higher HbA1c levels.
Authors: Abdul Hanif Khan Yusof Khan; Nor Fadhlina Zakaria; Muhammad Adil Zainal Abidin; Nor Azmi Kamaruddin Journal: Medicine (Baltimore) Date: 2021-07-30 Impact factor: 1.817
Authors: Abdul Hanif Khan Yusof Khan; Nor Fadhlina Zakaria; Muhammad Adil Zainal Abidin; Christopher Tiam Seong Lim; Nor Azmi Kamaruddin Journal: J ASEAN Fed Endocr Soc Date: 2020-05-02