PURPOSE OF REVIEW: This article reviews literature published over the period January 2011-June 2012 on biomarkers in major depression. RECENT FINDINGS: Although a large body of research accumulated over the past decades points to distinct biological mechanisms being involved in the pathophysiology of major depressive disorder (MDD), its precise pathobiology is not yet fully understood. In the last 2 years, substantial new research has been generated in an attempt to identify and characterize novel candidate biomarkers for MDD. This review provides an update on biomarker research in MDD and summarizes the most recent results from neuroimaging, genetic, epigenetic, and neurochemical studies in MDD. SUMMARY: Promising new findings report high diagnostic accuracy for metabonomic and epigenetic approaches as well as combinatorial functional neuroimaging approaches, which are currently representing the forefront of MDD biomarker development.
PURPOSE OF REVIEW: This article reviews literature published over the period January 2011-June 2012 on biomarkers in major depression. RECENT FINDINGS: Although a large body of research accumulated over the past decades points to distinct biological mechanisms being involved in the pathophysiology of major depressive disorder (MDD), its precise pathobiology is not yet fully understood. In the last 2 years, substantial new research has been generated in an attempt to identify and characterize novel candidate biomarkers for MDD. This review provides an update on biomarker research in MDD and summarizes the most recent results from neuroimaging, genetic, epigenetic, and neurochemical studies in MDD. SUMMARY: Promising new findings report high diagnostic accuracy for metabonomic and epigenetic approaches as well as combinatorial functional neuroimaging approaches, which are currently representing the forefront of MDD biomarker development.
Authors: Xian-Feng Shi; Lauren N Forrest; M Danielle Kuykendall; Andrew P Prescot; Young-Hoon Sung; Rebekah S Huber; Tracy L Hellem; Eun-Kee Jeong; Perry F Renshaw; Douglas G Kondo Journal: J Affect Disord Date: 2014-06-02 Impact factor: 4.839
Authors: David R Roalf; Simon N Vandekar; Laura Almasy; Kosha Ruparel; Theodore D Satterthwaite; Mark A Elliott; Jamie Podell; Sean Gallagher; Chad T Jackson; Konasale Prasad; Joel Wood; Michael F Pogue-Geile; Vishwajit L Nimgaonkar; Ruben C Gur; Raquel E Gur Journal: Biol Psychiatry Date: 2014-05-28 Impact factor: 13.382
Authors: Bhautesh D Jani; Gary McLean; Barbara I Nicholl; Sarah J E Barry; Naveed Sattar; Frances S Mair; Jonathan Cavanagh Journal: Front Hum Neurosci Date: 2015-02-02 Impact factor: 3.169