Literature DB >> 231537

Histopathological studies on renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine.

Y Hiasa, M Ohshima, C Iwata, T Tanikake.   

Abstract

Administration of a diet containing 0.2% N-ethyl-N-hydroxyethylnitrosamine (EHEN) for 2 weeks induced hepatocellular carcinoma in 3 and renal tubular cell tumors in 7 of 9 Wistar rats. Diet containing 0.1% EHEN induced renal tubular cell tumors in 6 of 10 rats, but no hepatocellular carcinomas. Both diets induced atypical cell population of tubules in the kidney, but no nephroblastoma.

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Year:  1979        PMID： 231537

Source DB:  PubMed          Journal:  Gan        ISSN： 0016-450X


  6 in total

Review 1.  Choosing The Right Animal Model for Renal Cancer Research.

Authors:  Paweł Sobczuk; Anna Brodziak; Mohammed Imran Khan; Stuti Chhabra; Michał Fiedorowicz; Marlena Wełniak-Kamińska; Kamil Synoradzki; Ewa Bartnik; Agnieszka Cudnoch-Jędrzejewska; Anna M Czarnecka
Journal:  Transl Oncol       Date:  2020-02-22       Impact factor: 4.243

2.  Experimental models of kidney tumors.

Authors:  E Nogueira; A Cardesa; U Mohr
Journal:  J Cancer Res Clin Oncol       Date:  1993       Impact factor: 4.553

3.  Effects of the oxazolidinedione anticonvulsants trimethadione and dimethadione and the barbiturate homolog 5,5-dimethylbarbituric acid on N-nitrosodiethylamine-initiated renal and hepatic carcinogenesis in the F344/NCr rat.

Authors:  B A Diwan; R W Nims; J R Henneman; J M Ward; R A Lubet; J M Rice
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

4.  Possible application to medium-term organ bioassays for renal carcinogenesis modifiers in rats treated with N-ethyl-N-hydroxyethylnitrosamine and unilateral nephrectomy.

Authors:  Y Hiasa; N Konishi; S Nakaoka; M Nakamura; S Nishii; Y Kitahori; M Ohshima
Journal:  Jpn J Cancer Res       Date:  1991-12

5.  Long-term exposure to the anti-inflammatory agent phenylbutazone induces kidney tumors in rats and liver tumors in mice.

Authors:  F Kari; J Bucher; J Haseman; S Eustis; J Huff
Journal:  Jpn J Cancer Res       Date:  1995-03

6.  Promoting effects of potassium dibasic phosphate on early-stage renal carcinogenesis in unilaterally nephrectomized rats treated with N-ethyl-N-hydroxyethylnitrosamine.

Authors:  Y Hiasa; N Konishi; S Nakaoka; T Nakamura; K Nishii; M Ohshima
Journal:  Jpn J Cancer Res       Date:  1992-07
  6 in total

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