Literature DB >> 23153530

BMP meets AML: induction of BMP signaling by a novel fusion gene promotes pediatric acute leukemia.

John D Crispino1, Michelle M Le Beau.   

Abstract

In this issue of Cancer Cell, Gruber et al. report that a significant proportion of children with acute megakaryoblastic leukemia acquire a translocation that confers enhanced BMP signaling and promotes self-renewal of hematopoietic progenitors. This study presents novel therapeutic targets that may lead to improved therapies for this aggressive leukemia.
Copyright © 2012 Elsevier Inc. All rights reserved.

Entities:  

Year:  2012        PMID： 23153530      PMCID： PMC3501979          DOI： 10.1016/j.ccr.2012.10.008

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  9 in total

Review 1.  Origins of chromosome translocations in childhood leukaemia.

Authors:  Mel F Greaves; Joe Wiemels
Journal:  Nat Rev Cancer       Date:  2003-09       Impact factor: 60.716

2.  Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome.

Authors:  Jeffrey W Taub; Gina Mundschau; Yubin Ge; Janet M Poulik; Faisal Qureshi; Tanya Jensen; S Jill James; Larry H Matherly; Joshua Wechsler; John D Crispino
Journal:  Blood       Date:  2004-09-01       Impact factor: 22.113

3.  BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling.

Authors:  Sandrine Jeanpierre; Franck Emmanuel Nicolini; Bastien Kaniewski; Charles Dumontet; Ruth Rimokh; Alain Puisieux; Véronique Maguer-Satta
Journal:  Blood       Date:  2008-07-29       Impact factor: 22.113

4.  Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation.

Authors:  Brenda J Chyla; Isabel Moreno-Miralles; Melissa A Steapleton; Mary Ann Thompson; Srividya Bhaskara; Michael Engel; Scott W Hiebert
Journal:  Mol Cell Biol       Date:  2008-08-18       Impact factor: 4.272

5.  Acute megakaryocytic leukemia: the Eastern Cooperative Oncology Group experience.

Authors:  M S Tallman; D Neuberg; J M Bennett; C J Francois; E Paietta; P H Wiernik; G Dewald; P A Cassileth; M M Oken; J M Rowe
Journal:  Blood       Date:  2000-10-01       Impact factor: 22.113

6.  Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome.

Authors:  Sébastien Malinge; Meghan Bliss-Moreau; Gina Kirsammer; Lauren Diebold; Timothy Chlon; Sandeep Gurbuxani; John D Crispino
Journal:  J Clin Invest       Date:  2012-02-22       Impact factor: 14.808

7.  The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.

Authors:  Thomas Mercher; Glen D Raffel; Sandra A Moore; Melanie G Cornejo; Dominique Baudry-Bluteau; Nicolas Cagnard; Jonathan L Jesneck; Yana Pikman; Dana Cullen; Ifor R Williams; Koichi Akashi; Hirokazu Shigematsu; Jean-Pierre Bourquin; Marco Giovannini; William Vainchenker; Ross L Levine; Benjamin H Lee; Olivier A Bernard; D Gary Gilliland
Journal:  J Clin Invest       Date:  2009-03-16       Impact factor: 14.808

8.  Role for MKL1 in megakaryocytic maturation.

Authors:  Ee-Chun Cheng; Qing Luo; Emanuela M Bruscia; Matthew J Renda; James A Troy; Stephanie A Massaro; David Tuck; Vincent Schulz; Shrikant M Mane; Nancy Berliner; Yi Sun; Stephan W Morris; Caihong Qiu; Diane S Krause
Journal:  Blood       Date:  2009-01-09       Impact factor: 22.113

9.  The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines.

Authors:  Yubin Ge; Tanya L Jensen; Mark L Stout; Robin M Flatley; Patrick J Grohar; Yaddanapudi Ravindranath; Larry H Matherly; Jeffrey W Taub
Journal:  Cancer Res       Date:  2004-01-15       Impact factor: 12.701
  9 in total
  5 in total

1.  LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling.

Authors:  Yanying Wang; Pingping Zhu; Jianjun Luo; Jing Wang; Zhiwei Liu; Wei Wu; Ying Du; Buqing Ye; Dongpeng Wang; Lei He; Weizheng Ren; Jianyi Wang; Xianhui Sun; Runsheng Chen; Yong Tian; Zusen Fan
Journal:  EMBO J       Date:  2019-07-23       Impact factor: 11.598

2.  AML-induced osteogenic differentiation in mesenchymal stromal cells supports leukemia growth.

Authors:  V Lokesh Battula; Phuong M Le; Jeffrey C Sun; Khoa Nguyen; Bin Yuan; Ximin Zhou; Sonali Sonnylal; Teresa McQueen; Vivian Ruvolo; Keith A Michel; Xiaoyang Ling; Rodrigo Jacamo; Elizabeth Shpall; Zhiqiang Wang; Arvind Rao; Gheath Al-Atrash; Marina Konopleva; R Eric Davis; Melvyn A Harrington; Catherine W Cahill; Carlos Bueso-Ramos; Michael Andreeff
Journal:  JCI Insight       Date:  2017-07-06

3.  DHH-RHEBL1 fusion transcript: a novel recurrent feature in the new landscape of pediatric CBFA2T3-GLIS2-positive acute myeloid leukemia.

Authors:  Riccardo Masetti; Marco Togni; Annalisa Astolfi; Martina Pigazzi; Elena Manara; Valentina Indio; Carmelo Rizzari; Sergio Rutella; Giuseppe Basso; Andrea Pession; Franco Locatelli
Journal:  Oncotarget       Date:  2013-10

4.  Towards integrated oncogenic marker recognition through mutual information-based statistically significant feature extraction: an association rule mining based study on cancer expression and methylation profiles.

Authors:  Saurav Mallik; Zhongming Zhao
Journal:  Quant Biol       Date:  2017-11-23

Review 5.  Osteogenic niche in the regulation of normal hematopoiesis and leukemogenesis.

Authors:  Phuong M Le; Michael Andreeff; Venkata Lokesh Battula
Journal:  Haematologica       Date:  2018-10-18       Impact factor: 9.941
  5 in total

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