Literature DB >> 23151985

Strategies to reverse endothelial dysfunction in diabetic nephropathy.

Shawn S Badal1, Farhad R Danesh.   

Abstract

Endothelial dysfunction underlies the basic pathophysiology of microvascular complications of diabetes. Endothelial dysfunction is associated with impaired nitric oxide (NO) availability. Since NO production is tightly regulated by endothelial nitric oxide synthase (eNOS), several therapeutic strategies have been investigated and proposed to improve eNOS bioavailability in the vasculature. The findings of Cheng et al. suggest that increased availability of eNOS may be an effective strategy in restoring endothelial function in patients with diabetic nephropathy.

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Year:  2012        PMID： 23151985      PMCID： PMC3914716          DOI： 10.1038/ki.2012.306

Source DB:  PubMed          Journal:  Kidney Int        ISSN： 0085-2538            Impact factor:   10.612


  10 in total

1.  Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice.

Authors:  Hui John Zhao; Suwan Wang; Huifang Cheng; Ming-zhi Zhang; Takamune Takahashi; Agnes B Fogo; Matthew D Breyer; Raymond C Harris
Journal:  J Am Soc Nephrol       Date:  2006-09-13       Impact factor: 10.121

2.  Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy.

Authors:  Takahiko Nakagawa; Waichi Sato; Olena Glushakova; Marcelo Heinig; Tracy Clarke; Martha Campbell-Thompson; Yukio Yuzawa; Mark A Atkinson; Richard J Johnson; Byron Croker
Journal:  J Am Soc Nephrol       Date:  2007-01-03       Impact factor: 10.121

3.  Increased plasma concentration of von Willebrand factor in insulin dependent diabetics with incipient nephropathy.

Authors:  T Jensen
Journal:  BMJ       Date:  1989-01-07

4.  The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

Authors:  Y Kureishi; Z Luo; I Shiojima; A Bialik; D Fulton; D J Lefer; W C Sessa; K Walsh
Journal:  Nat Med       Date:  2000-09       Impact factor: 53.440

5.  Effect of tetrahydrobiopterin on endothelial function in canine middle cerebral arteries.

Authors:  M Tsutsui; S Milstien; Z S Katusic
Journal:  Circ Res       Date:  1996-08       Impact factor: 17.367

6.  Features of endothelial dysfunction in early diabetic nephropathy.

Authors:  T Jensen; J Bjerre-Knudsen; B Feldt-Rasmussen; T Deckert
Journal:  Lancet       Date:  1989-03-04       Impact factor: 79.321

7.  Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase.

Authors:  Tomasz J Guzik; Shafi Mussa; Daniela Gastaldi; Jerzy Sadowski; Chandi Ratnatunga; Ravi Pillai; Keith M Channon
Journal:  Circulation       Date:  2002-04-09       Impact factor: 29.690

8.  Hypertension in mice lacking the gene for endothelial nitric oxide synthase.

Authors:  P L Huang; Z Huang; H Mashimo; K D Bloch; M A Moskowitz; J A Bevan; M C Fishman
Journal:  Nature       Date:  1995-09-21       Impact factor: 49.962

9.  Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors.

Authors:  J Vásquez-Vivar; B Kalyanaraman; P Martásek; N Hogg; B S Masters; H Karoui; P Tordo; K A Pritchard
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-04       Impact factor: 11.205

10.  Improvement of endothelial nitric oxide synthase activity retards the progression of diabetic nephropathy in db/db mice.

Authors:  Huifang Cheng; Hanmin Wang; Xiaofeng Fan; Paisit Paueksakon; Raymond C Harris
Journal:  Kidney Int       Date:  2012-07-11       Impact factor: 10.612
  10 in total
  6 in total

1.  Endothelial cell-specific overexpression of endothelial nitric oxide synthase in Ins2Akita mice exacerbates diabetic nephropathy.

Authors:  Mohan Natarajan; Samy L Habib; Robert L Reddick; Caroline R Delma; Krishnan Manickam; Thomas J Prihoda; Sherry L Werner; Sumathy Mohan
Journal:  J Diabetes Complications       Date:  2018-10-13       Impact factor: 2.852

Review 2.  Nitric oxide in the normal kidney and in patients with diabetic nephropathy.

Authors:  Paolo Tessari
Journal:  J Nephrol       Date:  2014-09-13       Impact factor: 3.902

3.  Enhancing eNOS activity with simultaneous inhibition of IKKβ restores vascular function in Ins2(Akita+/-) type-1 diabetic mice.

Authors:  Manickam Krishnan; Preethi Janardhanan; Linda Roman; Robert L Reddick; Mohan Natarajan; Rien van Haperen; Samy L Habib; Rini de Crom; Sumathy Mohan
Journal:  Lab Invest       Date:  2015-07-27       Impact factor: 5.662

4.  Endothelial nitric oxide synthase (eNOS) 4b/a polymorphism and the risk of diabetic nephropathy in type 2 diabetes mellitus: A meta-analysis.

Authors:  Ze-Jun Ma; Rui Chen; Hui-Zhu Ren; Xin Guo; Jun Guo Chen; Li-Ming Chen
Journal:  Meta Gene       Date:  2013-12-24

5.  Cinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagy.

Authors:  Ji Hee Lim; Hyung Wook Kim; Min Young Kim; Tae Woo Kim; Eun Nim Kim; Yaeni Kim; Sungjin Chung; Young Soo Kim; Bum Soon Choi; Yong-Soo Kim; Yoon Sik Chang; Hye Won Kim; Cheol Whee Park
Journal:  Cell Death Dis       Date:  2018-02-15       Impact factor: 8.469

Review 6.  Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes.

Authors:  Gina Manda; Alexandru-Ionel Checherita; Maria Victoria Comanescu; Mihail Eugen Hinescu
Journal:  Mediators Inflamm       Date:  2015-09-27       Impact factor: 4.711
  6 in total

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